Conjugates Derived from Lapatinib Derivatives with Cancer Cell Stemness Inhibitors Effectively Reversed Drug Resistance in Triple-Negative Breast Cancer.

Wang, Yuanjiang; Lv, Zhaodan; Chen, Feihong; Wang, Xing; Gou, Shaohua

Wang, Yuanjiang; Lv, Zhaodan; Chen, Feihong; Wang, Xing; Gou, Shaohua.

Afiliação

Wang Y; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing 211189, People's Republic of China.
Lv Z; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, People's Republic of China.
Chen F; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, People's Republic of China.
Wang X; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing 211189, People's Republic of China.
Gou S; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, People's Republic of China.

J Med Chem ; 64(17): 12877-12892, 2021 09 09.

Article em En | MEDLINE | ID: mdl-34435487

Assuntos

Antineoplásicos/farmacologia; Resistencia a Medicamentos Antineoplásicos; Lapatinib/análogos & derivados; Lapatinib/farmacologia; Células-Tronco Neoplásicas/efeitos dos fármacos; Neoplasias de Mama Triplo Negativas/tratamento farmacológico; Antineoplásicos/síntese química; Antineoplásicos/química; Descoberta de Drogas; Feminino; Humanos; Lapatinib/química

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Resistencia a Medicamentos Antineoplásicos / Neoplasias de Mama Triplo Negativas / Lapatinib / Antineoplásicos Limite: Female / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article

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