Germ Cell Derivation from Pluripotent Stem Cells for Understanding In Vitro Gametogenesis.
Cells
; 10(8)2021 07 26.
Article
em En
| MEDLINE
| ID: mdl-34440657
ABSTRACT
Assisted reproductive technologies (ARTs) have developed considerably in recent years; however, they cannot rectify germ cell aplasia, such as non-obstructive azoospermia (NOA) and oocyte maturation failure syndrome. In vitro gametogenesis is a promising technology to overcome infertility, particularly germ cell aplasia. Early germ cells, such as primordial germ cells, can be relatively easily derived from pluripotent stem cells (PSCs); however, further progression to post-meiotic germ cells usually requires a gonadal niche and signals from gonadal somatic cells. Here, we review the recent advances in in vitro male and female germ cell derivation from PSCs and discuss how this technique is used to understand the biological mechanism of gamete development and gain insight into its application in infertility.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Pluripotentes
/
Gametogênese
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Células Germinativas
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Cells
Ano de publicação:
2021
Tipo de documento:
Article