Extracellular acidity in tumor tissue upregulates programmed cell death protein 1 expression on tumor cells via proton-sensing G protein-coupled receptors.

Mori, Daichi; Tsujikawa, Takahiro; Sugiyama, Yoichiro; Kotani, Shin-Ichiro; Fuse, Shinya; Ohmura, Gaku; Arai, Akihito; Kawaguchi, Tsutomu; Hirano, Shigeru; Mazda, Osam; Kishida, Tsunao

Extracellular acidity in tumor tissue upregulates programmed cell death protein 1 expression on tumor cells via proton-sensing G protein-coupled receptors.

Mori, Daichi; Tsujikawa, Takahiro; Sugiyama, Yoichiro; Kotani, Shin-Ichiro; Fuse, Shinya; Ohmura, Gaku; Arai, Akihito; Kawaguchi, Tsutomu; Hirano, Shigeru; Mazda, Osam; Kishida, Tsunao.

Afiliação

Mori D; Department of Immunology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Tsujikawa T; Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Sugiyama Y; Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Kotani SI; Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Fuse S; Department of Immunology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Ohmura G; Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Arai A; Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Kawaguchi T; Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Hirano S; Department of Digestive Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Mazda O; Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Kishida T; Department of Immunology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Int J Cancer ; 149(12): 2116-2124, 2021 12 15.

Article em En | MEDLINE | ID: mdl-34460096

Assuntos

Antígeno B7-H1/genética; Neoplasias/imunologia; Receptores Acoplados a Proteínas G/metabolismo; Animais; Antígeno B7-H1/metabolismo; Linhagem Celular Tumoral/transplante; Conjuntos de Dados como Assunto; Modelos Animais de Doenças; Feminino; Regulação Neoplásica da Expressão Gênica/imunologia; Humanos; Concentração de Íons de Hidrogênio; Camundongos; Neoplasias/genética; Neoplasias/patologia; Prótons; RNA-Seq; Evasão Tumoral/genética; Microambiente Tumoral/genética; Microambiente Tumoral/imunologia; Regulação para Cima

Palavras-chave

GPCR; PD-L1; extracellular acidity; head and neck squamous cell carcinoma; melanoma of skin

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Acoplados a Proteínas G / Antígeno B7-H1 / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Int J Cancer Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão País de publicação: Estados Unidos

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google