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Diabetes increases the risk of bone fractures in patients on kidney replacement therapy: A Danish national cohort study.
Hauge, Sabina Chaudhary; Abrahamsen, Bo; Gislason, Gunnar; Olesen, Jonas Bjerring; Hommel, Kristine; Hansen, Ditte.
Afiliação
  • Hauge SC; Department of Nephrology, Copenhagen University Hospital - Herlev and Gentofte, Borgmester Ib Juuls Vej 1, 2730 Herlev, Denmark. Electronic address: sabina.chaudhary.hauge@regionh.dk.
  • Abrahamsen B; Department of Medicine, Holbæk Hospital, Smedelundsgade 60, 4300 Holbæk, Denmark.; Institute of Clinical Research, University of Southern Denmark, Winsløwparken 19, 3. Floor, 5000 Odense C, Copenhagen, Denmark; NDORMS, Botnar Centre, Oxford University, Windmill Road, Oxford, OX3 7LD, United Kingdom.
  • Gislason G; Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Gentofte Hospitalsvej 1, 2900 Hellerup, Denmark; The Danish Heart Foundation, Vognmagergade 7, 3. Floor, 1120 Copenhagen K, Denmark.
  • Olesen JB; Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Gentofte Hospitalsvej 1, 2900 Hellerup, Denmark.
  • Hommel K; Department of Medicine, Holbæk Hospital, Smedelundsgade 60, 4300 Holbæk, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.
  • Hansen D; Department of Nephrology, Copenhagen University Hospital - Herlev and Gentofte, Borgmester Ib Juuls Vej 1, 2730 Herlev, Denmark; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.
Bone ; 153: 116158, 2021 12.
Article em En | MEDLINE | ID: mdl-34461286
BACKGROUND: Patients treated with dialysis or living with a kidney transplant (kidney replacement therapy, KRT) have an increased risk of bone fracture. Patients with diabetes also have an increased risk of fracture. The aim of this study was to investigate whether the presence of diabetes in patients on KRT aggravates the risk of fracture. METHODS: Nationwide Danish registries were used in this retrospective cohort study. All prevalent adult patients on hemodialysis (HD) or peritoneal dialysis (PD) on 1st of January 2000 and all incident patients starting KRT (HD, PD, kidney transplanted (KTX)) until 31st of December 2011 were included in the KRT group. Adult persons not on KRT and without diabetes on 1st of January 2000 were used as a reference group. Patients were separated in groups with and without (+/-) diabetes. They were followed until first fracture, emigration, death, or end-of-study on 31st of December 2016. RESULTS: A total of 4,074,085 not on KRT +/- diabetes and 9053 patients on KRT +/- diabetes were included. Comparing the different groups with diabetes to the corresponding group without diabetes, the unadjusted HR (95% CI) for any first fracture were 1.2 (1.0-1.3) in the HD population, 1.4 (1.1-1.7) in the PD population, and 1.7 (1.4-2.2) in the KTX population. Further adjustments for age, sex, prior fractures, comorbidity and medication did not change these results significantly. CONCLUSIONS: Diabetes increases the risk of fracture in patients on KRT.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus / Fraturas Ósseas / Falência Renal Crônica Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Humans País/Região como assunto: Europa Idioma: En Revista: Bone Assunto da revista: METABOLISMO / ORTOPEDIA Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus / Fraturas Ósseas / Falência Renal Crônica Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Humans País/Região como assunto: Europa Idioma: En Revista: Bone Assunto da revista: METABOLISMO / ORTOPEDIA Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos