STAT3 is required for Smo-dependent signaling and mediates Smo-targeted treatment resistance and tumorigenesis in Shh medulloblastoma.

Yuan, Liangping; Zhang, Hongying; Liu, Jingbo; Malhotra, Anshu; Dey, Abhinav; Yu, Bing; Jella, Kishore Kumar; McSwain, Leon F; Schniederjan, Matthew J; MacDonald, Tobey J

Yuan, Liangping; Zhang, Hongying; Liu, Jingbo; Malhotra, Anshu; Dey, Abhinav; Yu, Bing; Jella, Kishore Kumar; McSwain, Leon F; Schniederjan, Matthew J; MacDonald, Tobey J.

Afiliação

Yuan L; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Zhang H; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Liu J; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Malhotra A; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Dey A; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Yu B; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Jella KK; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
McSwain LF; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Schniederjan MJ; Department of Pathology and Laboratory Medicine, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.
MacDonald TJ; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.

Mol Oncol ; 16(4): 1009-1025, 2022 02.

Article em En | MEDLINE | ID: mdl-34482626

Assuntos

Neoplasias Cerebelares; Meduloblastoma; Animais; Carcinogênese/genética; Neoplasias Cerebelares/patologia; Proteínas Hedgehog/metabolismo; Humanos; Meduloblastoma/tratamento farmacológico; Meduloblastoma/genética; Meduloblastoma/metabolismo; Camundongos; Fator de Transcrição STAT3/metabolismo; Receptor Smoothened/genética; Receptor Smoothened/metabolismo

Palavras-chave

STAT3; drug resistance; medulloblastoma; sonic hedgehog; tumorigenesis

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cerebelares / Meduloblastoma Limite: Animals / Humans Idioma: En Revista: Mol Oncol Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google