Colon fibroblasts from Pirc rats (F344/NTac-Apc<sup>am1137</sup> ) exhibit a proliferative and inflammatory phenotype that could support early stages of colon carcinogenesis.

Tortora, Katia; Margheri, Francesca; Luceri, Cristina; Mocali, Alessandra; Ristori, Sara; Magnelli, Lucia; Caderni, Giovanna; Giovannelli, Lisa

Colon fibroblasts from Pirc rats (F344/NTac-Apc^am1137 ) exhibit a proliferative and inflammatory phenotype that could support early stages of colon carcinogenesis.

Tortora, Katia; Margheri, Francesca; Luceri, Cristina; Mocali, Alessandra; Ristori, Sara; Magnelli, Lucia; Caderni, Giovanna; Giovannelli, Lisa.

Afiliação

Tortora K; NEUROFARBA Department, Pharmacology and Toxicology Section, University of Florence, Florence, Italy.
Margheri F; Department of Experimental and Clinical Biomedical Sciences Mario Serio, University of Florence, Florence, Italy.
Luceri C; NEUROFARBA Department, Pharmacology and Toxicology Section, University of Florence, Florence, Italy.
Mocali A; Department of Experimental and Clinical Biomedical Sciences Mario Serio, University of Florence, Florence, Italy.
Ristori S; NEUROFARBA Department, Pharmacology and Toxicology Section, University of Florence, Florence, Italy.
Magnelli L; Department of Experimental and Clinical Biomedical Sciences Mario Serio, University of Florence, Florence, Italy.
Caderni G; NEUROFARBA Department, Pharmacology and Toxicology Section, University of Florence, Florence, Italy.
Giovannelli L; NEUROFARBA Department, Pharmacology and Toxicology Section, University of Florence, Florence, Italy.

Int J Cancer ; 150(2): 362-373, 2022 01 15.

Article em En | MEDLINE | ID: mdl-34486752

Assuntos

Proliferação de Células; Colo/patologia; Neoplasias do Colo/patologia; Dano ao DNA; Fibroblastos/patologia; Genes APC; Inflamação/patologia; Animais; Apoptose; Colo/metabolismo; Neoplasias do Colo/etiologia; Neoplasias do Colo/metabolismo; Fibroblastos/metabolismo; Inflamação/etiologia; Inflamação/metabolismo; Mutação; Fenótipo; Ratos; Ratos Endogâmicos F344

Palavras-chave

Apc; CAFs; DNA damage response; colon cancer; cytoplasmic chromatin foci

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dano ao DNA / Genes APC / Colo / Neoplasias do Colo / Proliferação de Células / Fibroblastos / Inflamação Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Int J Cancer Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália País de publicação: Estados Unidos

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