The dominant strain of SARS-CoV-2 is a mosaicism.
Virus Res
; 305: 198553, 2021 11.
Article
em En
| MEDLINE
| ID: mdl-34487767
ABSTRACT
COVID-19 is seriously threatening human health all over the world. A comprehensive understanding of the genetic mechanisms driving the rapid evolution of its pathogen (SARS-CoV-2) is the key to controlling this pandemic. In this study, by comparing the entire genome sequences of SARS-CoV-2 isolates from Asia, Europe and America, and analyzing their phylogenetic histories, we found a lineage derived from a recombination event that likely occurred before March 2020. More importantly, the recombinant offspring has become the dominant strain responsible for more than one-third of the global cases in the pandemic. These results indicated that the recombination might have played a key role in the pandemic of the virus.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Genoma Viral
/
Evolução Molecular
/
Recombinação Homóloga
/
SARS-CoV-2
/
COVID-19
/
Mosaicismo
Limite:
Humans
País/Região como assunto:
Asia
/
Europa
Idioma:
En
Revista:
Virus Res
Assunto da revista:
VIROLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China