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Genetically and chemically tuned haemoglobin-albumin trimers with superior O2 transport efficiency.
Morita, Yoshitsugu; Takada, Ryoya; Saito, Asuka; Komatsu, Teruyuki.
Afiliação
  • Morita Y; Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan. komatsu@kc.chuo-u.ac.jp.
  • Takada R; Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan. komatsu@kc.chuo-u.ac.jp.
  • Saito A; Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan. komatsu@kc.chuo-u.ac.jp.
  • Komatsu T; Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan. komatsu@kc.chuo-u.ac.jp.
Chem Commun (Camb) ; 57(72): 9144-9147, 2021 Sep 09.
Article em En | MEDLINE | ID: mdl-34498647
Haemoglobin (Hb)-albumin (HSA) trimers were synthesized using five distinct Hb variants in which the structures were genetically and chemically tuned as an artificial O2 carrier and used as a red blood cell (RBC) substitute. The trimers were found to have moderately low O2 affinity (p50 = 23-34 Torr, 37 °C) and high co-operativity, yielding a maximum O2 transport efficiency 1.8-fold higher than that of human RBCs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxigênio / Hemoglobinas / Albuminas Limite: Humans Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxigênio / Hemoglobinas / Albuminas Limite: Humans Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão País de publicação: Reino Unido