Zebrafish as a Model to Evaluate a CRISPR/Cas9-Based Exon Excision Approach as a Future Treatment Option for <i>EYS</i>-Associated Retinitis Pigmentosa.

Schellens, Renske; de Vrieze, Erik; Graave, Pam; Broekman, Sanne; Nagel-Wolfrum, Kerstin; Peters, Theo; Kremer, Hannie; Collin, Rob W J; van Wijk, Erwin

Zebrafish as a Model to Evaluate a CRISPR/Cas9-Based Exon Excision Approach as a Future Treatment Option for EYS-Associated Retinitis Pigmentosa.

Schellens, Renske; de Vrieze, Erik; Graave, Pam; Broekman, Sanne; Nagel-Wolfrum, Kerstin; Peters, Theo; Kremer, Hannie; Collin, Rob W J; van Wijk, Erwin.

Afiliação

Schellens R; Department of Otorhinolaryngology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
de Vrieze E; Donders Institute for Brain Cognition and Behaviour, 6500 GL Nijmegen, The Netherlands.
Graave P; Department of Otorhinolaryngology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Broekman S; Donders Institute for Brain Cognition and Behaviour, 6500 GL Nijmegen, The Netherlands.
Nagel-Wolfrum K; Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Peters T; Department of Otorhinolaryngology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Kremer H; Institute for Molecular Physiology, Johannes Gutenberg-University Mainz, 55099 Mainz, Germany.
Collin RWJ; Institute for Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, 55099 Mainz, Germany.
van Wijk E; Department of Otorhinolaryngology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.

Int J Mol Sci ; 22(17)2021 Aug 25.

Article em En | MEDLINE | ID: mdl-34502064

Assuntos

Modelos Animais de Doenças; Proteínas do Olho/genética; Retinose Pigmentar/genética; Proteínas de Peixe-Zebra/genética; Animais; Sistemas CRISPR-Cas; Éxons; Proteínas do Olho/química; Proteínas do Olho/metabolismo; Terapia Genética/métodos; Fenótipo; Domínios Proteicos; Retinose Pigmentar/patologia; Retinose Pigmentar/terapia; Peixe-Zebra; Proteínas de Peixe-Zebra/química; Proteínas de Peixe-Zebra/metabolismo

Palavras-chave

CRISPR/Cas9; EYS; antisense oligonucleotides; exon skipping therapy; photoreceptors; retinitis pigmentosa; zebrafish

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Retinose Pigmentar / Proteínas de Peixe-Zebra / Modelos Animais de Doenças / Proteínas do Olho Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Holanda País de publicação: Suíça

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google