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Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates.
Herrmann, Frank; Hessmann, Manuela; Schaertl, Sabine; Berg-Rosseburg, Karola; Brown, Christopher J; Bursow, Galina; Chiki, Anass; Ebneth, Andreas; Gehrmann, Miriam; Hoeschen, Nicole; Hotze, Madlen; Jahn, Stefanie; Johnson, Peter D; Khetarpal, Vinod; Kiselyov, Alex; Kottig, Karsten; Ladewig, Stefanie; Lashuel, Hilal; Letschert, Sven; Mills, Matthew R; Petersen, Kathrin; Prime, Michael E; Scheich, Christoph; Schmiedel, Gerhard; Wityak, John; Liu, Longbin; Dominguez, Celia; Muñoz-Sanjuán, Ignacio; Bard, Jonathan A.
Afiliação
  • Herrmann F; Evotec SE, Essener Bogen 7, 22419, Hamburg, Germany.
  • Hessmann M; Evotec SE, Essener Bogen 7, 22419, Hamburg, Germany.
  • Schaertl S; Evotec SE, Essener Bogen 7, 22419, Hamburg, Germany.
  • Berg-Rosseburg K; Evotec SE, Essener Bogen 7, 22419, Hamburg, Germany.
  • Brown CJ; Evotec (U.K.) Ltd., 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, UK.
  • Bursow G; Evotec SE, Essener Bogen 7, 22419, Hamburg, Germany.
  • Chiki A; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland.
  • Ebneth A; Evotec SE, Essener Bogen 7, 22419, Hamburg, Germany.
  • Gehrmann M; Evotec SE, Essener Bogen 7, 22419, Hamburg, Germany.
  • Hoeschen N; Evotec SE, Essener Bogen 7, 22419, Hamburg, Germany.
  • Hotze M; Evotec SE, Essener Bogen 7, 22419, Hamburg, Germany.
  • Jahn S; Evotec SE, Essener Bogen 7, 22419, Hamburg, Germany.
  • Johnson PD; Evotec (U.K.) Ltd., 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, UK.
  • Khetarpal V; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, CA, 90045, USA.
  • Kiselyov A; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, CA, 90045, USA.
  • Kottig K; Evotec SE, Essener Bogen 7, 22419, Hamburg, Germany.
  • Ladewig S; Evotec SE, Essener Bogen 7, 22419, Hamburg, Germany.
  • Lashuel H; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland.
  • Letschert S; Evotec SE, Essener Bogen 7, 22419, Hamburg, Germany.
  • Mills MR; Evotec (U.K.) Ltd., 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, UK.
  • Petersen K; Evotec SE, Essener Bogen 7, 22419, Hamburg, Germany.
  • Prime ME; Evotec (U.K.) Ltd., 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, UK.
  • Scheich C; Evotec SE, Essener Bogen 7, 22419, Hamburg, Germany.
  • Schmiedel G; Evotec SE, Essener Bogen 7, 22419, Hamburg, Germany.
  • Wityak J; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, CA, 90045, USA.
  • Liu L; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, CA, 90045, USA.
  • Dominguez C; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, CA, 90045, USA.
  • Muñoz-Sanjuán I; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, CA, 90045, USA.
  • Bard JA; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, CA, 90045, USA. Jonathan.Bard@CHDIFoundation.org.
Sci Rep ; 11(1): 17977, 2021 09 09.
Article em En | MEDLINE | ID: mdl-34504195
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Huntington / Compostos Radiofarmacêuticos / Tomografia por Emissão de Pósitrons / Agregação Patológica de Proteínas / Agregados Proteicos / Proteína Huntingtina Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Huntington / Compostos Radiofarmacêuticos / Tomografia por Emissão de Pósitrons / Agregação Patológica de Proteínas / Agregados Proteicos / Proteína Huntingtina Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Reino Unido