A photoactivatable chemotherapeutic Ru(II) complex bearing bathocuproine ligand efficiently induces cell death in human malignant melanoma cells through a multi-mechanistic pathway.

Elias, Maria George; Mehanna, Stephanie; Elias, Elias; Khnayzer, Rony S; Daher, Costantine F

Elias, Maria George; Mehanna, Stephanie; Elias, Elias; Khnayzer, Rony S; Daher, Costantine F.

Afiliação

Elias MG; Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
Mehanna S; Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
Elias E; Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
Khnayzer RS; Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Chouran, Beirut, 1102-2801, Lebanon.
Daher CF; Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon. Electronic address: cdaher@lau.edu.lb.

Chem Biol Interact ; 348: 109644, 2021 Oct 01.

Article em En | MEDLINE | ID: mdl-34508709

Assuntos

Antineoplásicos/química; Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Melanoma/patologia; Fenantrolinas/química; Rutênio/química; Linhagem Celular Tumoral; Humanos; Ligantes; Fosfatidilinositol 3-Quinases/metabolismo

Palavras-chave

A375; Anticancer; Human melanoma; Photoactivated chemotherapy; Ruthenium complexes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenantrolinas / Rutênio / Apoptose / Melanoma / Antineoplásicos Limite: Humans Idioma: En Revista: Chem Biol Interact Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Líbano País de publicação: Irlanda

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