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Air travel-related outbreak of multiple SARS-CoV-2 variants.
Dhanasekaran, Vijaykrishna; Edwards, Kimberly M; Xie, Ruopeng; Gu, Haogao; Adam, Dillon C; Chang, Lydia D J; Cheuk, Sammi S Y; Gurung, Shreya; Krishnan, Pavithra; Ng, Daisy Y M; Liu, Gigi Y Z; Wan, Carrie K C; Cheng, Samuel S M; Tsang, Dominic N C; Cowling, Benjamin J; Peiris, Malik; Poon, Leo L M.
Afiliação
  • Dhanasekaran V; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Edwards KM; HKU-Pasteur Research Pole, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Xie R; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Gu H; HKU-Pasteur Research Pole, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Adam DC; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Chang LDJ; HKU-Pasteur Research Pole, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Cheuk SSY; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Gurung S; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Krishnan P; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Ng DYM; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Liu GYZ; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Wan CKC; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Cheng SSM; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Tsang DNC; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Cowling BJ; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Peiris M; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Poon LLM; Centre for Health Protection, Department of Health, The Government of Hong Kong Special Administrative Region, Hong Kong, China.
J Travel Med ; 28(8)2021 12 29.
Article em En | MEDLINE | ID: mdl-34542623
BACKGROUND: A large cluster of 59 cases were linked to a single flight with 146 passengers from New Delhi to Hong Kong in April 2021. This outbreak coincided with early reports of exponential pandemic growth in New Delhi, which reached a peak of > 400 000 newly confirmed cases on 7 May 2021. METHODS: Epidemiological information including date of symptom onset, date of positive-sample detection and travel and contact history for individual cases from this flight were collected. Whole genome sequencing was performed, and sequences were classified based on the dynamic Pango nomenclature system. Maximum-likelihood phylogenetic analysis compared sequences from this flight alongside other cases imported from India to Hong Kong on 26 flights between June 2020 and April 2021, as well as sequences from India or associated with India-related travel from February to April 2021 and 1217 reference sequences. RESULTS: Sequence analysis identified six lineages of SARS-CoV-2 belonging to two variants of concern (Alpha and Delta) and one variant of public health interest (Kappa) involved in this outbreak. Phylogenetic analysis confirmed at least three independent sub-lineages of Alpha with limited onward transmission, a superspreading event comprising 37 cases of Kappa and transmission of Delta to only one passenger. Additional analysis of another 26 flights from India to Hong Kong confirmed widespread circulation of all three variants in India since early March 2021. CONCLUSIONS: The broad spectrum of disease severity and long incubation period of SARS-CoV-2 pose a challenge for surveillance and control. As illustrated by this particular outbreak, opportunistic infections of SARS-CoV-2 can occur irrespective of variant lineage, and requiring a nucleic acid test within 72 hours of departure may be insufficient to prevent importation or in-flight transmission.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Viagem Aérea / Doença Relacionada a Viagens / COVID-19 Tipo de estudo: Prognostic_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: J Travel Med Assunto da revista: DOENCAS TRANSMISSIVEIS / SAUDE PUBLICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Viagem Aérea / Doença Relacionada a Viagens / COVID-19 Tipo de estudo: Prognostic_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: J Travel Med Assunto da revista: DOENCAS TRANSMISSIVEIS / SAUDE PUBLICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido