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A BRCA1 Coiled-Coil Domain Variant Disrupting PALB2 Interaction Promotes the Development of Mammary Tumors and Confers a Targetable Defect in Homologous Recombination Repair.
Pulver, Emilia M; Mukherjee, Chirantani; van de Kamp, Gerarda; Roobol, Stefan J; Rother, Magdalena B; van der Gulden, Hanneke; de Bruijn, Roebi; Lattanzio, Maria Valeria; van der Burg, Eline; Drenth, Anne Paulien; Verkaik, Nicole S; Hahn, Kerstin; Klarenbeek, Sjoerd; de Korte-Grimmerink, Renske; van de Ven, Marieke; Pritchard, Colin E J; Huijbers, Ivo J; Xia, Bing; van Gent, Dik C; Essers, Jeroen; van Attikum, Haico; Ray Chaudhuri, Arnab; Bouwman, Peter; Jonkers, Jos.
Afiliação
  • Pulver EM; Oncode Institute and Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • Mukherjee C; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • van de Kamp G; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Roobol SJ; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Rother MB; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • van der Gulden H; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
  • de Bruijn R; Oncode Institute and Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • Lattanzio MV; Oncode Institute and Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • van der Burg E; Oncode Institute and Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • Drenth AP; Oncode Institute and Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • Verkaik NS; Oncode Institute and Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • Hahn K; Oncode Institute and Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • Klarenbeek S; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • de Korte-Grimmerink R; Oncode Institute and Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • van de Ven M; Experimental Animal Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • Pritchard CEJ; Preclinical Intervention Unit, Mouse Clinic for Cancer and Aging (MCCA), The Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • Huijbers IJ; Preclinical Intervention Unit, Mouse Clinic for Cancer and Aging (MCCA), The Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • Xia B; Transgenic Core Facility, Mouse Clinic for Cancer and Aging (MCCA), The Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • van Gent DC; Transgenic Core Facility, Mouse Clinic for Cancer and Aging (MCCA), The Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • Essers J; Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey.
  • van Attikum H; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Ray Chaudhuri A; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Bouwman P; Department of Radiation Oncology, Department of Vascular Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Jonkers J; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Cancer Res ; 81(24): 6171-6182, 2021 12 15.
Article em En | MEDLINE | ID: mdl-34548335
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Neoplasias Mamárias Animais / Proteína BRCA1 / Reparo de DNA por Recombinação / Recombinação Homóloga / Proteína do Grupo de Complementação N da Anemia de Fanconi Limite: Animals Idioma: En Revista: Cancer Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Holanda País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Neoplasias Mamárias Animais / Proteína BRCA1 / Reparo de DNA por Recombinação / Recombinação Homóloga / Proteína do Grupo de Complementação N da Anemia de Fanconi Limite: Animals Idioma: En Revista: Cancer Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Holanda País de publicação: Estados Unidos