Dihydroartemisinin triggers ferroptosis in primary liver cancer cells by promoting and unfolded protein response­induced upregulation of CHAC1 expression.

Wang, Zhiwei; Li, Mingxing; Liu, Yuanfeng; Qiao, Zhentao; Bai, Tao; Yang, Ling; Liu, Bo

Dihydroartemisinin triggers ferroptosis in primary liver cancer cells by promoting and unfolded protein responseinduced upregulation of CHAC1 expression.

Wang, Zhiwei; Li, Mingxing; Liu, Yuanfeng; Qiao, Zhentao; Bai, Tao; Yang, Ling; Liu, Bo.

Afiliação

Wang Z; Department of Vascular and Endovascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Li M; Department of Vascular and Endovascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Liu Y; Department of Vascular and Endovascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Qiao Z; Department of Vascular and Endovascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Bai T; Department of Vascular and Endovascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Yang L; Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Liu B; Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.

Oncol Rep ; 46(5)2021 Nov.

Article em En | MEDLINE | ID: mdl-34558645

Assuntos

Artemisininas/farmacologia; Ferroptose/efeitos dos fármacos; Neoplasias Hepáticas/tratamento farmacológico; Resposta a Proteínas não Dobradas/efeitos dos fármacos; gama-Glutamilciclotransferase/metabolismo; Animais; Linhagem Celular Tumoral; Modelos Animais de Doenças; Humanos; Camundongos; RNA Interferente Pequeno/metabolismo; Regulação para Cima

Palavras-chave

CHAC1; DHA; ferroptosis; unfolded protein response

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artemisininas / Resposta a Proteínas não Dobradas / Gama-Glutamilciclotransferase / Ferroptose / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Oncol Rep Assunto da revista: NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article País de publicação: Grécia

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