Your browser doesn't support javascript.
loading
Neutralizing interleukin-6 in tumor-bearing mice does not abrogate behavioral fatigue induced by Lewis lung carcinoma.
Scott, Kiersten; Phan, Thien Trong; West, A Phillip; Taniguchi, Cullen M; Dantzer, Robert.
Afiliação
  • Scott K; Department of Symptom Research, University of Texas MD Anderson Cancer Center, Houston TX, USA.
  • Phan TT; Department of Symptom Research, University of Texas MD Anderson Cancer Center, Houston TX, USA.
  • West AP; Department of Molecular and Cellular Biology, School of Medicine, Texas A&M University, College Station TX, USA.
  • Taniguchi CM; Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston TX, USA.
  • Dantzer R; Department of Symptom Research, University of Texas MD Anderson Cancer Center, Houston TX, USA. Electronic address: rdantzer@mdanderson.org.
Behav Brain Res ; 417: 113607, 2022 01 24.
Article em En | MEDLINE | ID: mdl-34571117
Tumor growth is associated with metabolic reprogramming of various organs including the liver. This metabolic reprogramming is responsible for the development of behavioral fatigue represented by decreased voluntary wheel running in a murine model of lung cancer. To determine whether interleukin (IL-)6 induced by the tumor is responsible for the metabolic reprogramming, mice injected with Lewis lung carcinoma cells in the flank were treated with an anti-mouse IL-6 monoclonal neutralizing antibody using a 2 × 2 factorial design (+/- tumor and +/- anti-IL-6 antibody). Endpoints were represented by behavioral, metabolic and immune phenotypes. Despite its ability to abrogate the increase in plasma levels of IL-6 that was apparent in tumor-bearing mice and decrease inflammatory signaling in the liver, immunoneutralization of IL-6 had no effect on voluntary wheel running and did not modify the tumor-induced alterations in hepatic gene expression of inflammatory cytokines and metabolic factors. These negative results indicate that IL-6 does not mediate the communication between tumor and host in mice implanted with Lewis lung carcinoma.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-6 / Fadiga Muscular / Carcinoma Pulmonar de Lewis / Anticorpos Neutralizantes / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Behav Brain Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-6 / Fadiga Muscular / Carcinoma Pulmonar de Lewis / Anticorpos Neutralizantes / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Behav Brain Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Holanda