NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer.
Biomedicines
; 9(9)2021 Sep 21.
Article
em En
| MEDLINE
| ID: mdl-34572464
ABSTRACT
IκBα is considered to play an almost exclusive role as inhibitor of the NF-κB signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, NF-κB-binding affinity and function to the IκBα protein. In this review we discuss the main alterations of IκBα found in cancer and whether they are (most likely) associated with NF-κB-dependent or NF-κB-independent (moonlighting) activities of the protein.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Biomedicines
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Espanha