Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-&#954;B Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo.

Cykowiak, Marta; Krajka-Kuzniak, Violetta; Kleszcz, Robert; Kucinska, Malgorzata; Szaefer, Hanna; Piotrowska-Kempisty, Hanna; Plewinski, Adam; Murias, Marek; Baer-Dubowska, Wanda

Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo.

Cykowiak, Marta; Krajka-Kuzniak, Violetta; Kleszcz, Robert; Kucinska, Malgorzata; Szaefer, Hanna; Piotrowska-Kempisty, Hanna; Plewinski, Adam; Murias, Marek; Baer-Dubowska, Wanda.

Afiliação

Cykowiak M; Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 4, Swiecickiego Street, 60-781 Poznan, Poland.
Krajka-Kuzniak V; Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 4, Swiecickiego Street, 60-781 Poznan, Poland.
Kleszcz R; Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 4, Swiecickiego Street, 60-781 Poznan, Poland.
Kucinska M; Department of Toxicology, Poznan University of Medical Sciences, Dojazd 30, 60-631 Poznan, Poland.
Szaefer H; Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 4, Swiecickiego Street, 60-781 Poznan, Poland.
Piotrowska-Kempisty H; Department of Toxicology, Poznan University of Medical Sciences, Dojazd 30, 60-631 Poznan, Poland.
Plewinski A; Centre for Advanced Technologies, Adam Mickiewicz University, 10, Uniwersytetu Poznanskiego Street, 61-614 Poznan, Poland.
Murias M; Department of Toxicology, Poznan University of Medical Sciences, Dojazd 30, 60-631 Poznan, Poland.
Baer-Dubowska W; Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 4, Swiecickiego Street, 60-781 Poznan, Poland.

Nutrients ; 13(9)2021 Aug 28.

Article em En | MEDLINE | ID: mdl-34578877

Assuntos

Anticarcinógenos/farmacologia; Flavonoides/farmacologia; Hepatoblastoma/metabolismo; Isotiocianatos/farmacologia; Neoplasias Hepáticas/metabolismo; Fator 2 Relacionado a NF-E2/metabolismo; NF-kappa B/metabolismo; Propiofenonas/farmacologia; Animais; Anticarcinógenos/uso terapêutico; Apoptose; Inibidores de Ciclo-Oxigenase 2/farmacologia; Inibidores de Ciclo-Oxigenase 2/uso terapêutico; Regulação para Baixo; Combinação de Medicamentos; Flavonoides/uso terapêutico; Células Hep G2; Hepatoblastoma/tratamento farmacológico; Humanos; Isotiocianatos/uso terapêutico; Neoplasias Hepáticas/tratamento farmacológico; Masculino; Camundongos Endogâmicos BALB C; Camundongos Nus; NAD(P)H Desidrogenase (Quinona)/metabolismo; Propiofenonas/uso terapêutico; Transdução de Sinais; Superóxido Dismutase/metabolismo; Carga Tumoral; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

HepG2 and THLE-2 cells; NF-κB; Nrf2; mice xenograft model; phytochemicals combinations

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Propiofenonas / Flavonoides / NF-kappa B / Anticarcinógenos / Isotiocianatos / Hepatoblastoma / Fator 2 Relacionado a NF-E2 / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Nutrients Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Polônia País de publicação: Suíça

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