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N-(4-acetamidophenyl)-5-acetylfuran-2-carboxamide as a novel orally available diuretic that targets urea transporters with improved PD and PK properties.
Wang, Shuyuan; Xu, Yue; Zhao, Yan; Zhang, Shun; Li, Min; Li, Xiaowei; He, Jinzhao; Zhou, Hong; Ge, Zemei; Li, Runtao; Yang, Baoxue.
Afiliação
  • Wang S; Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China. Electronic address: shuyuan0127@outlook.com.
  • Xu Y; Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
  • Zhao Y; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China; College of Pharmacy, Inner Mongolia Medical University, 010110, China.
  • Zhang S; Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
  • Li M; Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
  • Li X; Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
  • He J; Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
  • Zhou H; Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
  • Ge Z; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China.
  • Li R; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China. Electronic address: lirt@bjmu.edu.cn.
  • Yang B; Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China. Electronic address: baoxue@bjmu.edu.cn.
Eur J Med Chem ; 226: 113859, 2021 Dec 15.
Article em En | MEDLINE | ID: mdl-34601246
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Furanos / Hiponatremia Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2021 Tipo de documento: Article País de publicação: França
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Furanos / Hiponatremia Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2021 Tipo de documento: Article País de publicação: França