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Tracing protein and proteome history with chronologies and networks: folding recapitulates evolution.
Caetano-Anollés, Gustavo; Aziz, M Fayez; Mughal, Fizza; Caetano-Anollés, Derek.
Afiliação
  • Caetano-Anollés G; Evolutionary Bioinformatics Laboratory, Department of Crop Sciences, University of Illinois, Urbana, Illinois, USA.
  • Aziz MF; C. R. Woese Institute for Genomic Biology, University of Illinois, Urbana, Illinois, USA.
  • Mughal F; Evolutionary Bioinformatics Laboratory, Department of Crop Sciences, University of Illinois, Urbana, Illinois, USA.
  • Caetano-Anollés D; Evolutionary Bioinformatics Laboratory, Department of Crop Sciences, University of Illinois, Urbana, Illinois, USA.
Expert Rev Proteomics ; 18(10): 863-880, 2021 10.
Article em En | MEDLINE | ID: mdl-34628994
INTRODUCTION: While the origin and evolution of proteins remain mysterious, advances in evolutionary genomics and systems biology are facilitating the historical exploration of the structure, function and organization of proteins and proteomes. Molecular chronologies are series of time events describing the history of biological systems and subsystems and the rise of biological innovations. Together with time-varying networks, these chronologies provide a window into the past. AREAS COVERED: Here, we review molecular chronologies and networks built with modern methods of phylogeny reconstruction. We discuss how chronologies of structural domain families uncover the explosive emergence of metabolism, the late rise of translation, the co-evolution of ribosomal proteins and rRNA, and the late development of the ribosomal exit tunnel; events that coincided with a tendency to shorten folding time. Evolving networks described the early emergence of domains and a late 'big bang' of domain combinations. EXPERT OPINION: Two processes, folding and recruitment appear central to the evolutionary progression. The former increases protein persistence. The later fosters diversity. Chronologically, protein evolution mirrors folding by combining supersecondary structures into domains, developing translation machinery to facilitate folding speed and stability, and enhancing structural complexity by establishing long-distance interactions in novel structural and architectural designs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Evolução Molecular / Proteoma Limite: Humans Idioma: En Revista: Expert Rev Proteomics Assunto da revista: BIOQUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Evolução Molecular / Proteoma Limite: Humans Idioma: En Revista: Expert Rev Proteomics Assunto da revista: BIOQUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido