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HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology.
Tanaka, Hikari; Kondo, Kanoh; Fujita, Kyota; Homma, Hidenori; Tagawa, Kazuhiko; Jin, Xiaocen; Jin, Meihua; Yoshioka, Yuki; Takayama, Sumire; Masuda, Hitomi; Tokuyama, Rie; Nakazaki, Yukoh; Saito, Takashi; Saido, Takaomi; Murayama, Shigeo; Ikura, Teikichi; Ito, Nobutoshi; Yamamori, Yu; Tomii, Kentaro; Bianchi, Marco E; Okazawa, Hitoshi.
Afiliação
  • Tanaka H; Department of Neuropathology, Medical Research Institute and Center for Brain Integration Research, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Kondo K; Department of Neuropathology, Medical Research Institute and Center for Brain Integration Research, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Fujita K; Department of Neuropathology, Medical Research Institute and Center for Brain Integration Research, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Homma H; Department of Neuropathology, Medical Research Institute and Center for Brain Integration Research, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Tagawa K; Department of Neuropathology, Medical Research Institute and Center for Brain Integration Research, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Jin X; Department of Neuropathology, Medical Research Institute and Center for Brain Integration Research, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Jin M; Department of Neuropathology, Medical Research Institute and Center for Brain Integration Research, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Yoshioka Y; Department of Neuropathology, Medical Research Institute and Center for Brain Integration Research, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Takayama S; Department of Neuropathology, Medical Research Institute and Center for Brain Integration Research, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Masuda H; Chiome Bioscience, Inc., Sumitomo Fudosan Nishi-shinjuku Building No. 6, 3-12-1 Honmachi, Shibuya-ku, Tokyo, 151-0071, Japan.
  • Tokuyama R; Chiome Bioscience, Inc., Sumitomo Fudosan Nishi-shinjuku Building No. 6, 3-12-1 Honmachi, Shibuya-ku, Tokyo, 151-0071, Japan.
  • Nakazaki Y; Chiome Bioscience, Inc., Sumitomo Fudosan Nishi-shinjuku Building No. 6, 3-12-1 Honmachi, Shibuya-ku, Tokyo, 151-0071, Japan.
  • Saito T; Department of Neurocognitive Science, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-ku, Mizuho-cho, Nagoya, Aichi, 467-8601, Japan.
  • Saido T; Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
  • Murayama S; Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.
  • Ikura T; Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders, Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Suita, Osaka, Japan.
  • Ito N; Department of Structural Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Yamamori Y; Department of Structural Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Tomii K; Intelligent Bioinformatics Research Team, Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology, 2-4-7, Aomi, Koto-ku, Tokyo, 135-0064, Japan.
  • Bianchi ME; Intelligent Bioinformatics Research Team, Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology, 2-4-7, Aomi, Koto-ku, Tokyo, 135-0064, Japan.
  • Okazawa H; Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Commun Biol ; 4(1): 1175, 2021 10 11.
Article em En | MEDLINE | ID: mdl-34635772
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dano ao DNA / Transdução de Sinais / Proteína HMGB1 / Reparo do DNA / Doença de Alzheimer / Autoantígeno Ku Limite: Animals Idioma: En Revista: Commun Biol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dano ao DNA / Transdução de Sinais / Proteína HMGB1 / Reparo do DNA / Doença de Alzheimer / Autoantígeno Ku Limite: Animals Idioma: En Revista: Commun Biol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão País de publicação: Reino Unido