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Metal-Organic Framework-Stabilized High Internal Phase Pickering Emulsions Based on Computer Simulation for Curcumin Encapsulation: Comprehensive Characterization and Stability Mechanism.
Ma, Peihua; Zhang, Jinglin; Teng, Zi; Zhang, Yuan; Bauchan, Gary R; Luo, Yaguang; Liu, Dongxia; Wang, Qin.
Afiliação
  • Ma P; Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, Maryland 20742, United States.
  • Zhang J; Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, Maryland 20742, United States.
  • Teng Z; Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, Maryland 20742, United States.
  • Zhang Y; Agricultural Research Service, Beltsville Agricultural Research Center, Food Quality Laboratory, U.S. Department of Agriculture, Beltsville, Maryland 20705, United States.
  • Bauchan GR; Department of Chemistry and Biochemistry, College of Computer, Mathematical and Natural Science, University of Maryland, College Park, Maryland 20742, United States.
  • Luo Y; Agricultural Research Service, Soybean Genomics and Improvement Laboratory, Electron and Confocal Microscopy Unit, U.S. Department of Agriculture, Beltsville, Maryland 20705, United States.
  • Liu D; Agricultural Research Service, Beltsville Agricultural Research Center, Food Quality Laboratory, U.S. Department of Agriculture, Beltsville, Maryland 20705, United States.
  • Wang Q; Department of Chemistry and Biochemistry, College of Computer, Mathematical and Natural Science, University of Maryland, College Park, Maryland 20742, United States.
ACS Omega ; 6(40): 26556-26565, 2021 Oct 12.
Article em En | MEDLINE | ID: mdl-34661010
High internal phase Pickering emulsions (HIPPEs) have taken a center stage in the arena of delivery systems in the food industry because of their high loading capacity and stability. In addition, metal-organic frameworks (MOFs), a type of cutting-edge designable porous scaffolding material, have attracted attention in reticular chemistry, which satisfies fundamental demands for delivery research in the past years. Here, we demonstrate a novel metal-organic framework (MOF)-stabilized HIPPE delivery system for hydrophobic phytochemicals. First, a novel high-biocompatibility and stable MOF particle, UiO-66-NH2, was selected from atomic simulation screening, which showed proper electronegativity and amphiphilic properties to develop the HIPPE system. Monodispersed UiO-66-NH2 nanoparticles with the particle size of 161.36 nm were then prepared via solvothermal synthesization. Pickering emulsions with inner phase ratios from 50 to 80% with varied contents of polyethylene glycol (PEG) were prepared by in situ high-pressure homogenization, and their physicochemical properties including crystallography, morphology, and rheology were systematically characterized. Subsequently, curcumin, a model antioxidant, was loaded in the HIPPE system and named cur@UiO-66-NH2/HIPPE. It exhibited high loading capacity, up to 6.93 ± 0.41%, and encapsulation efficiency (19.76 ± 3.84%). This novel MOF nanoparticle-stabilized HIPPE delivery system could be practically utilized for other bioactive components and antimicrobial agents, which would find applications in food safety and biomedical areas in the future.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Omega Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Omega Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos