Mechanism-Based Inactivation of Mycobacterium tuberculosis Isocitrate Lyase 1 by (2R,3S)-2-Hydroxy-3-(nitromethyl)succinic acid.

Mellott, Drake M; Torres, Dan; Krieger, Inna V; Cameron, Scott A; Moghadamchargari, Zahra; Laganowsky, Arthur; Sacchettini, James C; Meek, Thomas D; Harris, Lawrence D

Mechanism-Based Inactivation of Mycobacterium tuberculosis Isocitrate Lyase 1 by (2R,3S)-2-Hydroxy-3-(nitromethyl)succinic acid.

Mellott, Drake M; Torres, Dan; Krieger, Inna V; Cameron, Scott A; Moghadamchargari, Zahra; Laganowsky, Arthur; Sacchettini, James C; Meek, Thomas D; Harris, Lawrence D.

Afiliação

Mellott DM; Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, United States.
Torres D; The Ferrier Research Institute, Victoria University of Wellington, Wellington 5046, New Zealand.
Krieger IV; Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, United States.
Cameron SA; The Ferrier Research Institute, Victoria University of Wellington, Wellington 5046, New Zealand.
Moghadamchargari Z; The Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1010, New Zealand.
Laganowsky A; Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.
Sacchettini JC; Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.
Meek TD; Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, United States.
Harris LD; Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.

J Am Chem Soc ; 143(42): 17666-17676, 2021 10 27.

Article em En | MEDLINE | ID: mdl-34664502

Assuntos

Inibidores Enzimáticos/química; Isocitrato Liase/antagonistas & inibidores; Mycobacterium tuberculosis/enzimologia; Succinatos/química; Inibidores Enzimáticos/síntese química; Inibidores Enzimáticos/metabolismo; Glioxilatos/química; Glioxilatos/metabolismo; Isocitrato Liase/química; Isocitrato Liase/metabolismo; Cinética; Modelos Químicos; Nitrocompostos/química; Nitrocompostos/metabolismo; Propionatos/química; Propionatos/metabolismo; Ligação Proteica; Succinatos/síntese química; Succinatos/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Succinatos / Inibidores Enzimáticos / Isocitrato Liase / Mycobacterium tuberculosis Tipo de estudo: Prognostic_studies Idioma: En Revista: J Am Chem Soc Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

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