Harnessing autophagy to fight SARS-CoV-2: An update in view of recent drug development efforts.
J Cell Biochem
; 123(2): 155-160, 2022 02.
Article
em En
| MEDLINE
| ID: mdl-34668225
ABSTRACT
Drug repurposing is an attractive option for identifying new treatment strategies, in particular in extraordinary situations of urgent need such as the current coronavirus disease 2019 (Covid-19) pandemic. Recently, the World Health Organization announced testing of three drugs as potential Covid-19 therapeutics that are known for their dampening effect on the immune system. Thus, the underlying concept of selecting these drugs is to temper the potentially life-threatening overshooting of the immune system reacting to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. This viewpoint discusses the possibility that the impact of these and other drugs on autophagy contributes to their therapeutic effect by hampering the SARS-CoV-2 life cycle.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
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Autofagia
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Reposicionamento de Medicamentos
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Pandemias
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Mesilato de Imatinib
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Infliximab
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Artesunato
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SARS-CoV-2
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Tratamento Farmacológico da COVID-19
Limite:
Humans
Idioma:
En
Revista:
J Cell Biochem
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Alemanha