Phase-Based Cortical Synchrony Is Affected by Prematurity.
Cereb Cortex
; 32(10): 2265-2276, 2022 05 14.
Article
em En
| MEDLINE
| ID: mdl-34668522
ABSTRACT
Inter-areal synchronization by phase-phase correlations (PPCs) of cortical oscillations mediates many higher neurocognitive functions, which are often affected by prematurity, a globally prominent neurodevelopmental risk factor. Here, we used electroencephalography to examine brain-wide cortical PPC networks at term-equivalent age, comparing human infants after early prematurity to a cohort of healthy controls. We found that prematurity affected these networks in a sleep state-specific manner, and the differences between groups were also frequency-selective, involving brain-wide connections. The strength of synchronization in these networks was predictive of clinical outcomes in the preterm infants. These findings show that prematurity affects PPC networks in a clinically significant manner, suggesting early functional biomarkers of later neurodevelopmental compromise that may be used in clinical or translational studies after early neonatal adversity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido Prematuro
/
Eletroencefalografia
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Humans
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Infant
/
Newborn
Idioma:
En
Revista:
Cereb Cortex
Assunto da revista:
CEREBRO
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Finlândia