In Utero Fetal Therapy: Stem Cells, Cell Transplantation, Gene Therapy, and CRISPR-Cas9.
Clin Obstet Gynecol
; 64(4): 861-875, 2021 12 01.
Article
em En
| MEDLINE
| ID: mdl-34668889
ABSTRACT
In utero fetal therapy offers the opportunity to prevent and treat diseases with a cellular or genetic basis. Components of successful fetal treatment include isolation of a replacement cell population, in utero stem cell transplantation, cell engraftment with fetal immune tolerance, and ongoing cell function. Fetal gene therapy with CRISPR-Cas9 represents an exciting potential therapy for genetic diseases not amenable to gene supplementation via adenoviral vector transduction. These fetal therapies have unique ethical and safety considerations. Clinical trials for in utero cell therapy are underway, as additional discoveries in stem cell biology and gene therapy move closer to clinical translation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transplante de Células-Tronco Hematopoéticas
/
Terapias Fetais
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Doenças Fetais
Aspecto:
Ethics
Limite:
Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Clin Obstet Gynecol
Ano de publicação:
2021
Tipo de documento:
Article