Trypanocidal Activity of Dysphania ambrosioides, Lippia alba, and Tetradenia riparia Essential Oils against Trypanosoma cruzi.
Chem Biodivers
; 18(12): e2100678, 2021 Dec.
Article
em En
| MEDLINE
| ID: mdl-34669244
ABSTRACT
Despite the current treatments against Chagas Disease (CD), this vector-borne parasitic disease remains a serious public health concern. In this study, we have explored the inâ
vitro and/or inâ
vivo trypanocidal and cytotoxic activities of the essential oils (EOs) obtained from Dysphania ambrosioides (L.) Mosyakin & Clemants (Amaranthaceae) (DA-EO), Lippia alba (Mill.) N.E. Brown (Verbenaceae) (LA-EO), and Tetradenia riparia (Hochst.) Codd (Lamiaceae) (TR-EO) grown in Brazil Southeast. DA-EO was the most active against the trypomastigote and amastigote forms inâ
vitro; the IC50 values were 8.7 and 12.2â
µg mL-1 , respectively. The EOs displayed moderate toxicity against LLCMK2 cells, but the DA-EO showed high selectivity index (SI) for trypomastigote (SI=33.2) and amastigote (SI=11.7) forms. Treatment with 20â
mg/kg DA-EO, LA-EO, or TR-EO for 20â
days by intraperitoneal administration reduced parasitemia by 6.36 %, 4.74 %, and 32.68 % on dayâ
7 and by 12.04 %, 27.96 %, and 65.5 % on dayâ
9. These results indicated that DA-EO, LA-EO, and TR-EO have promising trypanocidal potential inâ
vitro, whereas TR-EO has also potential trypanocidal effects inâ
vivo.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tripanossomicidas
/
Trypanosoma cruzi
/
Óleos Voláteis
/
Lamiaceae
/
Amaranthaceae
/
Lippia
Limite:
Animals
Idioma:
En
Revista:
Chem Biodivers
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Brasil