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Genetic polymorphisms in the mEH gene in relation to tobacco smoking: role in lung cancer susceptibility and survival in north Indian patients with lung cancer undergoing platinum-based chemotherapy.
Walia, Harleen Kaur; Singh, Navneet; Sharma, Siddharth.
Afiliação
  • Walia HK; Department of Biotechnology, Thapar Institute of Engineering & Technology, Patiala 147004, India.
  • Singh N; Department of Pulmonary Medicine, Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh 160012, India.
  • Sharma S; Department of Biotechnology, Thapar Institute of Engineering & Technology, Patiala 147004, India.
Future Oncol ; 17(35): 4925-4946, 2021 Dec.
Article em En | MEDLINE | ID: mdl-34672683
Lay abstract Microsomal epoxide hydrolase (mEH) is an enzyme that plays a defensive role against chemicals. In this study, the relationship between the variation of the epoxide hydrolase and the risk of lung cancer was investigated and its role in the survival of patients with lung cancer was evaluated. The study comprised 550 cases and 550 controls. Genotyping was carried out using molecular biology tools and was followed by statistical analysis. The variant genotype of the EPHX1 gene was not associated with the risk of lung cancer, even based on histology. The variant form of the EPHX1 gene was found to be a risk factor for smokers. The Tyr/His genotype was associated with the risk of lung cancer in male subjects. Patients carrying the variant form of the EPHX1 gene (His139Arg) experienced better survival. The heterozygous genotype of the EPHX1Tyr113His gene was related to longer survival time in patients who received cisplatin/carboplatin along with irinotecan. The EPHX1 Tyr113His polymorphism is associated with LC risk in smokers and is a potential prognostic factor for OS of patients with small-cell lung cancer (SCLC) after irinotecan therapy and might increase the likelihood of lymph node metastasis; EPHX1His139Arg exhibited better survival, especially in patients with SCLC.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Suscetibilidade a Doenças / Epóxido Hidrolases / Fumar Tabaco / Neoplasias Pulmonares / Microssomos Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Future Oncol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Índia País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Suscetibilidade a Doenças / Epóxido Hidrolases / Fumar Tabaco / Neoplasias Pulmonares / Microssomos Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Future Oncol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Índia País de publicação: Reino Unido