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Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A.
Wortmann, Lars; Bräuer, Nico; Holton, Simon J; Irlbacher, Horst; Weiske, Jörg; Lechner, Christian; Meier, Robin; Karén, Jakob; Siöberg, Catrine Berthold; Pütter, Vera; Christ, Clara D; Ter Laak, Antonius; Lienau, Philip; Lesche, Ralf; Nicke, Barbara; Cheung, Shing-Hu; Bauser, Marcus; Haegebarth, Andrea; von Nussbaum, Franz; Mumberg, Dominik; Lemos, Clara.
Afiliação
  • Wortmann L; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany.
  • Bräuer N; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany.
  • Holton SJ; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany.
  • Irlbacher H; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany.
  • Weiske J; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany.
  • Lechner C; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany.
  • Meier R; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany.
  • Karén J; Pelago Bioscience AB, Banvaktsvägen 20, 171 48 Solna, Sweden.
  • Siöberg CB; Pelago Bioscience AB, Banvaktsvägen 20, 171 48 Solna, Sweden.
  • Pütter V; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany.
  • Christ CD; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany.
  • Ter Laak A; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany.
  • Lienau P; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany.
  • Lesche R; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany.
  • Nicke B; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany.
  • Cheung SH; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany.
  • Bauser M; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany.
  • Haegebarth A; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany.
  • von Nussbaum F; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany.
  • Mumberg D; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany.
  • Lemos C; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany.
J Med Chem ; 64(21): 15883-15911, 2021 11 11.
Article em En | MEDLINE | ID: mdl-34699202
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfotransferases (Aceptor do Grupo Álcool) / Inibidores Enzimáticos / Descoberta de Drogas / Naftiridinas Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfotransferases (Aceptor do Grupo Álcool) / Inibidores Enzimáticos / Descoberta de Drogas / Naftiridinas Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Estados Unidos