Your browser doesn't support javascript.
loading
Biomarkers of subclinical atherosclerosis in patients with psoriasis.
Kaiser, Hannah; Wang, Xing; Kvist-Hansen, Amanda; Krakauer, Martin; Gørtz, Peter Michael; McCauley, Benjamin D; Skov, Lone; Becker, Christine; Hansen, Peter Riis.
Afiliação
  • Kaiser H; Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark. lilian.hannah.kaiser@regionh.dk.
  • Wang X; Department of Dermatology and Allergy, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark. lilian.hannah.kaiser@regionh.dk.
  • Kvist-Hansen A; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. lilian.hannah.kaiser@regionh.dk.
  • Krakauer M; Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Gørtz PM; Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.
  • McCauley BD; Department of Dermatology and Allergy, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.
  • Skov L; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Becker C; Department of Clinical Physiology and Nuclear Medicine, Herlev and Gentofte Hospital, Hellerup, Denmark.
  • Hansen PR; Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, University Hospital, Copenhagen, Denmark.
Sci Rep ; 11(1): 21438, 2021 11 02.
Article em En | MEDLINE | ID: mdl-34728734
ABSTRACT
Psoriasis is linked with increased risk of cardiovascular disease (CVD) that is underestimated by traditional risk stratification. We conducted a large-scale plasma proteomic analysis by use of a proximity extension assay in 85 patients with a history of moderate-to-severe psoriasis with or without established atherosclerotic CVD. Differentially expressed proteins associated with CVD were correlated with subclinical atherosclerotic markers including vascular inflammation determined by 18F-fluorodeoxyglucose positron emission tomography/computed tomography, carotid intima-media thickness (CIMT), carotid artery plaques, and coronary artery calcium score (CCS) in the patients without CVD and statin treatment. We also examined the association between the neutrophil-to-lymphocyte ratio (NLR) and subclinical atherosclerosis. In unadjusted analyses, growth differentiation factor-15 (GDF-15) levels and NLR were increased, while tumor necrosis factor (TNF)-related activation-inducing ligand (TRANCE) and TNF-related apoptosis-induced ligand (TRAIL) levels were decreased in patients with established CVD compared to those without CVD. Among patients with psoriasis without CVD and statin treatment, GDF-15 levels were negatively associated with vascular inflammation in the ascending aorta and entire aorta, and positively associated with CIMT and CCS. NLR was positively associated with vascular inflammation in the carotid arteries. Our data suggest that circulating GDF-15 levels and NLR might serve as biomarkers of subclinical atherosclerosis in patients with psoriasis.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Linfócitos / Biomarcadores / Doenças Cardiovasculares / Artérias Carótidas / Aterosclerose / Neutrófilos Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Dinamarca

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Linfócitos / Biomarcadores / Doenças Cardiovasculares / Artérias Carótidas / Aterosclerose / Neutrófilos Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Dinamarca