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An engineered IL-21 with half-life extension enhances anti-tumor immunity as a monotherapy or in combination with PD-1 or TIGIT blockade.
Liu, Hongchuan; Wang, Rui; An, Duopeng; Liu, Hui; Ye, Fan; Li, Baoxian; Zhang, Jing; Liu, Peixiang; Zhang, Xuyao; Yao, Sheng; Zhong, Ziyang; Feng, Hui; Feng, Meiqing.
Afiliação
  • Liu H; Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, Shanghai, China; Shanghai Junshi Biosciences Co., Ltd., Shanghai, China.
  • Wang R; Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, Shanghai, China.
  • An D; Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, Shanghai, China.
  • Liu H; Shanghai Junshi Biosciences Co., Ltd., Shanghai, China.
  • Ye F; Anwita Biosciences, INC., San Carlos, CA, United States.
  • Li B; Shanghai Junshi Biosciences Co., Ltd., Shanghai, China.
  • Zhang J; Shanghai Junshi Biosciences Co., Ltd., Shanghai, China.
  • Liu P; Shanghai Junshi Biosciences Co., Ltd., Shanghai, China.
  • Zhang X; Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, Shanghai, China.
  • Yao S; Shanghai Junshi Biosciences Co., Ltd., Shanghai, China.
  • Zhong Z; Anwita Biosciences, INC., San Carlos, CA, United States.
  • Feng H; Shanghai Junshi Biosciences Co., Ltd., Shanghai, China. Electronic address: hui_feng@topalliancebio.com.
  • Feng M; Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, Shanghai, China. Electronic address: fmq@fudan.edu.cn.
Int Immunopharmacol ; 101(Pt A): 108307, 2021 Dec.
Article em En | MEDLINE | ID: mdl-34735918
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Imunológicos / Interleucinas / Receptor de Morte Celular Programada 1 / Antineoplásicos Limite: Animals Idioma: En Revista: Int Immunopharmacol Assunto da revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Holanda
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Imunológicos / Interleucinas / Receptor de Morte Celular Programada 1 / Antineoplásicos Limite: Animals Idioma: En Revista: Int Immunopharmacol Assunto da revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Holanda