How palmitoylation affects trafficking and signaling of membrane receptors.
Biol Cell
; 114(2): 61-72, 2022 Feb.
Article
em En
| MEDLINE
| ID: mdl-34738237
ABSTRACT
S-acylation (or palmitoylation) is a reversible post-translational modification (PTM) that modulates protein activity, signalization and trafficking. Palmitoylation was found to significantly impact the activity of various membrane receptors involved in either pathogen entry, such as CCR5 (for HIV) and anthrax toxin receptors, cell proliferation (epidermal growth factor receptor), cardiac function (ß-Adrenergic receptor), or synaptic function (AMPA receptor). Palmitoylation of these membrane receptors indeed affects not only their internalization, localization, and activation, but also other PTMs such as phosphorylation. In this review, we discuss recent results showing how palmitoylation differently affects the biology of these membrane receptors.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de AMPA
/
Lipoilação
Idioma:
En
Revista:
Biol Cell
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
França