Dissolving microneedle rollers for rapid transdermal drug delivery.
Drug Deliv Transl Res
; 12(2): 459-471, 2022 02.
Article
em En
| MEDLINE
| ID: mdl-34743303
ABSTRACT
Dissolving microneedle patch (DMNP) is a minimally invasive and painless self-administration device. However, due to skin deformation, it is difficult to apply it on the large areas of skin or curved skin as the patch size increased for DMNP. Here, we propose a polyvinyl alcohol (PVA)-based dissolving microneedle roller (DMNR) device that can be used for delivering drugs rapidly on the large surface areas or curved skin and does not need to be attached on the skin all the time during drug delivery. The hypoglycemic effect of insulin-loaded DMNRs for transdermal delivery of insulin was studied on the type 1 diabetic rat models. It was found that the insulin-loaded DMNR has an immediate and effective hypoglycemic effect that the blood glucose level reduced below to 50% of original blood glucose at 1 h after DMNRs administrated.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicemia
/
Agulhas
Limite:
Animals
Idioma:
En
Revista:
Drug Deliv Transl Res
Ano de publicação:
2022
Tipo de documento:
Article