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Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo.
Saenz, Steven A; Local, Andrea; Carr, Tiffany; Shakya, Arvind; Koul, Shivsmriti; Hu, Haiqing; Chourb, Lisa; Stedman, Justin; Malley, Jenna; D'Agostino, Laura Akullian; Shanmugasundaram, Veerabahu; Malona, John; Schwartz, C Eric; Beebe, Lisa; Clements, Meghan; Rajaraman, Ganesh; Cho, John; Jiang, Lan; Dubrovskiy, Alex; Kreilein, Matt; Shimanovich, Roman; Hamann, Lawrence G; Escoubet, Laure; Ellis, J Michael.
Afiliação
  • Saenz SA; Immunology, Cardiovascular & Fibrosis, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America.
  • Local A; Oncogenesis Thematic Research Center, Bristol Myers Squibb, San Diego, California, United States of America.
  • Carr T; Immunology, Cardiovascular & Fibrosis, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America.
  • Shakya A; Oncogenesis Thematic Research Center, Bristol Myers Squibb, San Diego, California, United States of America.
  • Koul S; Oncogenesis Thematic Research Center, Bristol Myers Squibb, San Diego, California, United States of America.
  • Hu H; Preclinical Candidate Optimization, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America.
  • Chourb L; Preclinical Candidate Optimization, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America.
  • Stedman J; Preclinical Candidate Optimization, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America.
  • Malley J; Nonclinical Development, Celgene Corporation, Cambridge, Massachusetts, United States of America.
  • D'Agostino LA; Small Molecule Drug Discovery, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America.
  • Shanmugasundaram V; Small Molecule Drug Discovery, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America.
  • Malona J; Drug Substance Development, Bristol Myers Squibb, Summit, New Jersey, United States of America.
  • Schwartz CE; Drug Substance Development, Bristol Myers Squibb, Summit, New Jersey, United States of America.
  • Beebe L; Preclinical Candidate Optimization, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America.
  • Clements M; Nonclinical Development, Celgene Corporation, Cambridge, Massachusetts, United States of America.
  • Rajaraman G; Nonclinical Development, Celgene Corporation, Cambridge, Massachusetts, United States of America.
  • Cho J; Immunology & Inflammation, Celgene Corporation, Cambridge, Massachusetts, United States of America.
  • Jiang L; Immunology, Cardiovascular & Fibrosis, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America.
  • Dubrovskiy A; Immunology, Cardiovascular & Fibrosis, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America.
  • Kreilein M; Drug Substance Development, Bristol Myers Squibb, Summit, New Jersey, United States of America.
  • Shimanovich R; Preclinical Candidate Optimization, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America.
  • Hamann LG; Small Molecule Drug Discovery, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America.
  • Escoubet L; Oncogenesis Thematic Research Center, Bristol Myers Squibb, San Diego, California, United States of America.
  • Ellis JM; Small Molecule Drug Discovery, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America.
PLoS One ; 16(11): e0248034, 2021.
Article em En | MEDLINE | ID: mdl-34752458
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Expressão Gênica / Membro 1 do Grupo F da Subfamília 1 de Receptores Nucleares / Células Th17 / Inflamação Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Expressão Gênica / Membro 1 do Grupo F da Subfamília 1 de Receptores Nucleares / Células Th17 / Inflamação Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos