JQ1 attenuates psychostimulant- but not opioid-induced conditioned place preference.
Behav Brain Res
; 418: 113644, 2022 02 10.
Article
em En
| MEDLINE
| ID: mdl-34757001
ABSTRACT
Epigenetic mechanisms play important roles in the neurobiology of substance use disorder. In particular, bromodomain and extra-terminal domain (BET) proteins, a class of histone acetylation readers, have been found to regulate cocaine conditioned behaviors, but their role in the behavioral response to other drugs of abuse remains unclear. To address this knowledge gap, we examined the effects of the BET inhibitor, JQ1, on nicotine, amphetamine, morphine, and oxycodone conditioned place preference (CPP). Similar to previous cocaine studies, systemic administration of JQ1 caused a dose-dependent reduction in the acquisition of amphetamine and nicotine CPP in male mice. However, in opioid studies, JQ1 did not alter morphine or oxycodone CPP. Investigating the effects of JQ1 on other types of learning and memory, we found that JQ1 did not alter the acquisition of contextual fear conditioning. Together, these results indicate that BET proteins play an important role in the acquisition of psychostimulant-induced CPP but not the acquisition of opioid-induced CPP nor contextual fear conditioning.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Azepinas
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Triazóis
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Comportamento Animal
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Condicionamento Psicológico
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Relação Dose-Resposta a Droga
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Estimulantes do Sistema Nervoso Central
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Anestésicos Locais
Limite:
Animals
Idioma:
En
Revista:
Behav Brain Res
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos