CRISPR-Cas9 Mediated Exonic Disruption for HIV-1 Elimination.

Herskovitz, Jonathan; Hasan, Mahmudul; Patel, Milankumar; Blomberg, Wilson R; Cohen, Jacob D; Machhi, Jatin; Shahjin, Farah; Mosley, R Lee; McMillan, JoEllyn; Kevadiya, Bhavesh D; Gendelman, Howard E

Herskovitz, Jonathan; Hasan, Mahmudul; Patel, Milankumar; Blomberg, Wilson R; Cohen, Jacob D; Machhi, Jatin; Shahjin, Farah; Mosley, R Lee; McMillan, JoEllyn; Kevadiya, Bhavesh D; Gendelman, Howard E.

Afiliação

Herskovitz J; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-5900 USA. Electronic address: jonathan.herskovitz@unmc.edu.
Hasan M; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800 USA; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198-6120 USA.
Patel M; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800 USA.
Blomberg WR; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800 USA; School of Medicine, Creighton University Medical Center, Omaha, NE 68124.
Cohen JD; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800 USA.
Machhi J; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800 USA.
Shahjin F; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800 USA.
Mosley RL; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800 USA.
McMillan J; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800 USA.
Kevadiya BD; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800 USA.
Gendelman HE; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-5900 USA; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800 USA; Department of Pharmaceutical Sciences, University of Nebraska Medical

EBioMedicine ; 73: 103678, 2021 Nov.

Article em En | MEDLINE | ID: mdl-34774454

Assuntos

Sistemas CRISPR-Cas; Éxons; Edição de Genes; Infecções por HIV/terapia; Infecções por HIV/virologia; HIV-1/genética; Linhagem Celular; Sequência Conservada; Imunofluorescência; Marcação de Genes; Genes Reporter; Terapia Genética; Vetores Genéticos/administração & dosagem; Vetores Genéticos/genética; Genoma Viral; Humanos; Lipossomos; Macrófagos/metabolismo; Macrófagos/virologia; Nanopartículas; Provírus/genética; Interferência de RNA; RNA Mensageiro/administração & dosagem; RNA Mensageiro/genética; Produtos do Gene rev do Vírus da Imunodeficiência Humana/genética; Produtos do Gene tat do Vírus da Imunodeficiência Humana/genética; RNA Guia de Sistemas CRISPR-Cas

Palavras-chave

CRISPR delivery; Clustered regularly interspaced short palindromic repeat; Human immunodeficiency virus type one; Latent infection; RNA loaded Lipid nanoparticles (rLNP); Viral eradication

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Éxons / HIV-1 / Sistemas CRISPR-Cas / Edição de Genes Limite: Humans Idioma: En Revista: EBioMedicine Ano de publicação: 2021 Tipo de documento: Article País de publicação: Holanda

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