A mathematical model to evaluate the role of memory B and T cells in heterologous secondary dengue infection.
J Theor Biol
; 534: 110961, 2022 02 07.
Article
em En
| MEDLINE
| ID: mdl-34774663
ABSTRACT
We propose a mathematical model to investigate the antibody-dependent enhancement (ADE) phenomenon during secondary dengue infection. The model consists of an ODE system that describes the interaction of the dengue virus with macrophages and memory B and T cell role during the infection. The qualitative model analysis is done in terms of memory B and T cell cloning parameters and the basic reproduction number R0. In the absence of memory B and T cell cloning, if R0<1 the dengue virus population extinguishes, while for R0>1, it tends asymptotically to a positive equilibrium. However, when we consider the memory B cell cloning, it is possible to occur dengue infection even when R0<1. Memory T cells have an essential role in eliminating the possibility of ADE occurrence when R0<1.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dengue
/
Vírus da Dengue
/
Coinfecção
Tipo de estudo:
Qualitative_research
Limite:
Humans
Idioma:
En
Revista:
J Theor Biol
Ano de publicação:
2022
Tipo de documento:
Article