Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma.
Neuropathol Appl Neurobiol
; 48(3): e12773, 2022 04.
Article
em En
| MEDLINE
| ID: mdl-34799864
ABSTRACT
TERT promoter mutations have been associated with increased risk of recurrence in meningioma cohorts, thus a potential biomarker for aggressive phenotypes. A main purpose of refining tumour classification is better predictions on the patient level. We compiled data from previous published cohorts to investigate patient-level predictions of recurrence based on TERTp-mut status. Implementation of TERTp-mut into the WHO grading led to better patient prognostication by improved prediction of recurrence. Our results support implementation of TERTp-mut into diagnostics and classification of meningiomas.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Telomerase
/
Neoplasias Meníngeas
/
Meningioma
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Neuropathol Appl Neurobiol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Dinamarca