GRADE guidance 24 optimizing the integration of randomized and non-randomized studies of interventions in evidence syntheses and health guidelines.
J Clin Epidemiol
; 142: 200-208, 2022 02.
Article
em En
| MEDLINE
| ID: mdl-34800676
ABSTRACT
BACKGROUND AND OBJECTIVE:
This is the 24th in the ongoing series of articles describing the GRADE approach for assessing the certainty of a body of evidence in systematic reviews and health technology assessments and how to move from evidence to recommendations in guidelines.METHODS:
Guideline developers and authors of systematic reviews and other evidence syntheses use randomized controlled studies (RCTs) and non-randomized studies of interventions (NRSI) as sources of evidence for questions about health interventions. RCTs with low risk of bias are the most trustworthy source of evidence for estimating relative effects of interventions because of protection against confounding and other biases. However, in several instances, NRSI can still provide valuable information as complementary, sequential, or replacement evidence for RCTs.RESULTS:
In this article we offer guidance on the decision regarding when to search for and include either or both types of studies in systematic reviews to inform health recommendations.CONCLUSION:
This work aims to help methodologists in review teams, technology assessors, guideline panelists, and anyone conducting evidence syntheses using GRADE.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Projetos de Pesquisa
/
Avaliação da Tecnologia Biomédica
Tipo de estudo:
Clinical_trials
/
Guideline
/
Health_technology_assessment
/
Policy_brief
/
Prognostic_studies
/
Systematic_reviews
Aspecto:
Implementation_research
Limite:
Humans
Idioma:
En
Revista:
J Clin Epidemiol
Assunto da revista:
EPIDEMIOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article