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Heightened splenic and bone marrow uptake of 18F-FDG PET/CT is associated with systemic inflammation and subclinical atherosclerosis by CCTA in psoriasis: An observational study.
Patel, Nidhi H; Osborne, Michael T; Teague, Heather; Parel, Philip; Svirydava, Mariya; Sorokin, Alexander V; Teklu, Meron; Manyak, Grigory; Zhou, Wunan; Pantoja, Carla; Scott, Colin; Playford, Martin P; Kapoor, Promita; Rodante, Justin A; Keel, Andrew; Chen, Marcus; Tawakol, Ahmed; Mehta, Nehal N.
Afiliação
  • Patel NH; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Osborne MT; Cardiac Imaging Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Teague H; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Parel P; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Svirydava M; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Sorokin AV; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Teklu M; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Manyak G; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Zhou W; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Pantoja C; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Scott C; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Playford MP; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Kapoor P; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Rodante JA; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Keel A; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Chen M; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Tawakol A; Cardiac Imaging Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Mehta NN; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: nehal.mehta@nih.gov.
Atherosclerosis ; 339: 20-26, 2021 12.
Article em En | MEDLINE | ID: mdl-34808541
ABSTRACT
BACKGROUND AND

AIMS:

Psoriasis is an immune-mediated inflammatory disease with increased risk of myocardial infarction. Preclinical studies in psoriasis models show an association between chronic inflammation and immune cell proliferation in the spleen and bone marrow (BM). We sought to test the hypothesis that splenic and BM 18F-fluorodeoxyglucose (18F-FDG) uptake is heightened in psoriasis and that higher uptake associates with systemic inflammation and subclinical atherosclerotic disease measures in this cohort.

METHODS:

Multimodality imaging and biomarker assays were performed in 240 participants (210 with psoriasis and 30 healthy). Splenic and BM uptake was obtained using 18F-FDG positron emission tomography/computed tomography (PET/CT). Coronary artery plaque characteristics including non-calcified burden (NCB) and lipid rich necrotic core (LRNC) were quantified using a dedicated software for CT angiography. All analyses were performed with StataIC 16 (Stata Corp., College Station, TX, USA).

RESULTS:

Splenic and BM 18F-FDG uptake was increased in psoriasis (vs. healthy volunteers) and significantly associated with proatherogenic lipids, immune cells and systemic inflammation. Higher splenic 18F-FDG uptake associated with higher total coronary burden (ß = 0.37; p<0.001), NCB (ß = 0.39; p<0.001), and LRNC (ß = 0.32; p<0.001) in fully adjusted models. Similar associations were seen for BM 18F-FDG uptake in adjusted models (ß = 0.38; ß = 0.41; ß = 0.24; respectively, all p<0.001).

CONCLUSIONS:

Heightened splenic and BM uptake of 18F-FDG is associated with proatherogenic lipids, immune cells, inflammatory markers and coronary artery disease. These findings provide insights into atherogenic mechanisms in psoriasis and suggest that immune cell proliferation in the spleen and BM is associated with subclinical atherosclerosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Aterosclerose Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Atherosclerosis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Aterosclerose Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Atherosclerosis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos