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New dihydronaphthothiophene derivatives by the biological transformation of seriniquinone using marine-derived actinomycete Streptomyces albogriseolus OM27-12.
Ishida, Kohei; Tanaka, Teruki; Nagai, Kenichiro; Furuichi, Yoshimasa; Terahara, Takeshi; Ando, Masashi; Tsukamasa, Yasuyuki; Fukuda, Takashi.
Afiliação
  • Ishida K; Department of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.
  • Tanaka T; Department of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.
  • Nagai K; Microbial Chemistry and Medicinal Research Laboratories, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
  • Furuichi Y; Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Tokyo, Japan.
  • Terahara T; Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Tokyo, Japan.
  • Ando M; Department of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.
  • Tsukamasa Y; Department of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.
  • Fukuda T; Department of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan. fukudata@nara.kindai.ac.jp.
J Antibiot (Tokyo) ; 75(1): 9-15, 2022 01.
Article em En | MEDLINE | ID: mdl-34840331
ABSTRACT
Seriniquinone was originally isolated as a melanoma-selective anti-cancer agent from a culture broth of marine bacteria. Pharmacological studies on its selectivity and unique target are ongoing. A new dihydronaphthothiophene (1) was synthesized by the biological transformation of seriniquinone using marine-derived actinomycete Streptomyces albogriseolus OM27-12, and its derivatives (2-4) were chemically synthesized. Compounds 1-4 exhibited selective cytotoxic activity against melanoma and improved solubility.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Streptomyces / Actinobacteria / Antibióticos Antineoplásicos Limite: Humans Idioma: En Revista: J Antibiot (Tokyo) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Streptomyces / Actinobacteria / Antibióticos Antineoplásicos Limite: Humans Idioma: En Revista: J Antibiot (Tokyo) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão