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Functionalization of filled radioactive multi-walled carbon nanocapsules by arylation reaction for in vivo delivery of radio-therapy.
Gajewska, Agnieszka; Wang, Julie T-W; Klippstein, Rebecca; Martincic, Markus; Pach, Elzbieta; Feldman, Robert; Saccavini, Jean-Claude; Tobias, Gerard; Ballesteros, Belén; Al-Jamal, Khuloud T; Da Ros, Tatiana.
Afiliação
  • Gajewska A; INSTM, Trieste Unit & Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via Licio Giorgieri 1, 34127 Trieste, Italy. daros@units.it.
  • Wang JT; School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London SE1 9NH, UK. khuloud.al-jamal@kcl.ac.uk.
  • Klippstein R; School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London SE1 9NH, UK. khuloud.al-jamal@kcl.ac.uk.
  • Martincic M; Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, 08193 Bellaterra, Barcelona, Spain.
  • Pach E; Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and the Barcelona Institute of Science and Technology, Campus UAB, 08193 Bellaterra, Barcelona, Spain.
  • Feldman R; Cis Bio International Ion Beam Applications SA (IBA), 91400 Saclay, France.
  • Saccavini JC; Cis Bio International Ion Beam Applications SA (IBA), 91400 Saclay, France.
  • Tobias G; Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, 08193 Bellaterra, Barcelona, Spain.
  • Ballesteros B; Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and the Barcelona Institute of Science and Technology, Campus UAB, 08193 Bellaterra, Barcelona, Spain.
  • Al-Jamal KT; School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London SE1 9NH, UK. khuloud.al-jamal@kcl.ac.uk.
  • Da Ros T; INSTM, Trieste Unit & Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via Licio Giorgieri 1, 34127 Trieste, Italy. daros@units.it.
J Mater Chem B ; 10(1): 47-56, 2021 12 22.
Article em En | MEDLINE | ID: mdl-34843615
Functionalized multi-walled carbon nanotubes (MWCNTs) containing radioactive salts are proposed as a potential system for radioactivity delivery. MWCNTs are loaded with isotopically enriched 152-samarium chloride (152SmCl3), the ends of the MWCNTs are sealed by high temperature treatment, and the encapsulated 152Sm is neutron activated to radioactive 153Sm. The external walls of the radioactive nanocapsules are functionalized through arylation reaction, to introduce hydrophilic chains and increase the water dispersibility of CNTs. The organ biodistribution profiles of the nanocapsules up to 24 h are assessed in naïve mice and different tumor models in vivo. By quantitative γ-counting, 153SmCl3@MWCNTs-NH2 exhibite high accumulation in organs without leakage of the internal radioactive material to the bloodstream. In the treated mice, highest uptake is detected in the lung followed by the liver and spleen. Presence of tumors in brain or lung does not increase percentage accumulation of 153SmCl3@MWCNTs-NH2 in the respective organs, suggesting the absence of the enhanced permeation and retention effect. This study presents a chemical functionalization protocol that is rapid (∼one hour) and can be applied to filled radioactive multi-walled carbon nanocapsules to improve their water dispersibility for systemic administration for their use in targeted radiotherapy.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Materiais Biocompatíveis / Nanotubos de Carbono / Nanocápsulas / Glioma / Neoplasias Pulmonares / Melanoma Tipo de estudo: Guideline Limite: Animals Idioma: En Revista: J Mater Chem B Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Materiais Biocompatíveis / Nanotubos de Carbono / Nanocápsulas / Glioma / Neoplasias Pulmonares / Melanoma Tipo de estudo: Guideline Limite: Animals Idioma: En Revista: J Mater Chem B Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália País de publicação: Reino Unido