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First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53.
Nowak, Radoslaw P; Tumber, Anthony; Hendrix, Eline; Ansari, Mohammad Salik Zeya; Sabatino, Manuela; Antonini, Lorenzo; Andrijes, Regina; Salah, Eidarus; Mautone, Nicola; Pellegrini, Francesca Romana; Simelis, Klemensas; Kawamura, Akane; Johansson, Catrine; Passeri, Daniela; Pellicciari, Roberto; Ciogli, Alessia; Del Bufalo, Donatella; Ragno, Rino; Coleman, Mathew L; Trisciuoglio, Daniela; Mai, Antonello; Oppermann, Udo; Schofield, Christopher J; Rotili, Dante.
Afiliação
  • Nowak RP; Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Headington OX3 7LD, U.K.
  • Tumber A; Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Headington OX3 7LD, U.K.
  • Hendrix E; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, 12, Mansfield Road, University of Oxford, Oxford OX1 3TA, U.K.
  • Ansari MSZ; Institute of Cancer and Genomic Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
  • Sabatino M; Institute of Molecular Biology and Pathology (IMBP), National Research Council (CNR) c/o Department of Biology and Biotechnology "Charles Darwin" Sapienza University of Rome, Via degli Apuli 4, Rome 00185, Italy.
  • Antonini L; Rome Center for Molecular Design, Department of Chemistry and Technology of Drugs, ″Sapienza″ University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy.
  • Andrijes R; Rome Center for Molecular Design, Department of Chemistry and Technology of Drugs, ″Sapienza″ University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy.
  • Salah E; Institute of Cancer and Genomic Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
  • Mautone N; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, 12, Mansfield Road, University of Oxford, Oxford OX1 3TA, U.K.
  • Pellegrini FR; Department of Chemistry and Technology of Drugs, ″Sapienza″ University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy.
  • Simelis K; Institute of Molecular Biology and Pathology (IMBP), National Research Council (CNR) c/o Department of Biology and Biotechnology "Charles Darwin" Sapienza University of Rome, Via degli Apuli 4, Rome 00185, Italy.
  • Kawamura A; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, 12, Mansfield Road, University of Oxford, Oxford OX1 3TA, U.K.
  • Johansson C; Chemistry - School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.
  • Passeri D; Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Headington OX3 7LD, U.K.
  • Pellicciari R; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, 12, Mansfield Road, University of Oxford, Oxford OX1 3TA, U.K.
  • Ciogli A; TES Pharma S.r.l. Via P. Togliatti 20, Corciano, Perugia 06073, Italy.
  • Del Bufalo D; TES Pharma S.r.l. Via P. Togliatti 20, Corciano, Perugia 06073, Italy.
  • Ragno R; Department of Chemistry and Technology of Drugs, ″Sapienza″ University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy.
  • Coleman ML; Preclinical Models and New Therapeutic Agents Unit, IRCCS-Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome 00144, Italy.
  • Trisciuoglio D; Rome Center for Molecular Design, Department of Chemistry and Technology of Drugs, ″Sapienza″ University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy.
  • Mai A; Institute of Cancer and Genomic Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
  • Oppermann U; Institute of Molecular Biology and Pathology (IMBP), National Research Council (CNR) c/o Department of Biology and Biotechnology "Charles Darwin" Sapienza University of Rome, Via degli Apuli 4, Rome 00185, Italy.
  • Schofield CJ; Department of Chemistry and Technology of Drugs, ″Sapienza″ University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy.
  • Rotili D; Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Headington OX3 7LD, U.K.
J Med Chem ; 64(23): 17031-17050, 2021 12 09.
Article em En | MEDLINE | ID: mdl-34843649
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribossomos / Proteínas Nucleares / Dioxigenases / Inibidores Enzimáticos / Histona Desmetilases Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribossomos / Proteínas Nucleares / Dioxigenases / Inibidores Enzimáticos / Histona Desmetilases Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Estados Unidos