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An immunodominant NP105-113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease.
Peng, Yanchun; Felce, Suet Ling; Dong, Danning; Penkava, Frank; Mentzer, Alexander J; Yao, Xuan; Liu, Guihai; Yin, Zixi; Chen, Ji-Li; Lu, Yongxu; Wellington, Dannielle; Wing, Peter A C; Dominey-Foy, Delaney C C; Jin, Chen; Wang, Wenbo; Hamid, Megat Abd; Fernandes, Ricardo A; Wang, Beibei; Fries, Anastasia; Zhuang, Xiaodong; Ashley, Neil; Rostron, Timothy; Waugh, Craig; Sopp, Paul; Hublitz, Philip; Beveridge, Ryan; Tan, Tiong Kit; Dold, Christina; Kwok, Andrew J; Rich-Griffin, Charlotte; Dejnirattisa, Wanwisa; Liu, Chang; Kurupati, Prathiba; Nassiri, Isar; Watson, Robert A; Tong, Orion; Taylor, Chelsea A; Kumar Sharma, Piyush; Sun, Bo; Curion, Fabiola; Revale, Santiago; Garner, Lucy C; Jansen, Kathrin; Ferreira, Ricardo C; Attar, Moustafa; Fry, Jeremy W; Russell, Rebecca A; Stauss, Hans J; James, William; Townsend, Alain.
Afiliação
  • Peng Y; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Felce SL; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.
  • Dong D; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.
  • Penkava F; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Mentzer AJ; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Yao X; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Liu G; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.
  • Yin Z; CAMS Key Laboratory of Tumor Immunology and Radiation Therapy, Xinjiang Tumor Hospital, Xinjiang Medical University, Urumqi, China.
  • Chen JL; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
  • Lu Y; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Wellington D; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Wing PAC; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.
  • Dominey-Foy DCC; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Jin C; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.
  • Wang W; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Hamid MA; Beijing You'an Hospital, Capital Medical University, Beijing, China.
  • Fernandes RA; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Wang B; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.
  • Fries A; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Zhuang X; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Ashley N; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.
  • Rostron T; Department of Pathology, University of Cambridge, Cambridge, UK.
  • Waugh C; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Sopp P; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.
  • Hublitz P; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.
  • Beveridge R; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Tan TK; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.
  • Dold C; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Kwok AJ; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.
  • Rich-Griffin C; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Dejnirattisa W; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.
  • Liu C; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Kurupati P; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.
  • Nassiri I; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Watson RA; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.
  • Tong O; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Taylor CA; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.
  • Kumar Sharma P; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Sun B; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Curion F; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Revale S; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Garner LC; Single Cell Facility, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
  • Jansen K; Sequencing Facility, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
  • Ferreira RC; Flow Cytometry Facility, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
  • Attar M; Flow Cytometry Facility, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
  • Fry JW; Genome Engineering Facility, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
  • Russell RA; Virus Screening Facility, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
  • Stauss HJ; Oxford Vaccine Group, Department of Paediatrics, and NIHR Oxford Biomedical Research Centre, Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, UK.
  • James W; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Townsend A; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Nat Immunol ; 23(1): 50-61, 2022 01.
Article em En | MEDLINE | ID: mdl-34853448
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T Citotóxicos / Antígeno HLA-B7 / Epitopos Imunodominantes / Proteínas do Nucleocapsídeo / SARS-CoV-2 Tipo de estudo: Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T Citotóxicos / Antígeno HLA-B7 / Epitopos Imunodominantes / Proteínas do Nucleocapsídeo / SARS-CoV-2 Tipo de estudo: Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Estados Unidos