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Status of epileptic spasms: A study of 21 children.
Caraballo, Roberto; Semprino, Marcos; Fasulo, Lorena; Reyes, Gabriela; Chacón, Santiago; Gallo, Adolfo; Buompadre, Celeste.
Afiliação
  • Caraballo R; Department of Neurology, Hospital de Pediatría Juan P. Garrahan, Buenos Aires, Argentina. Electronic address: rhcaraballo@arnet.com.ar.
  • Semprino M; Department of Neurology, Clinica San Lucas, Neuquen, Argentina.
  • Fasulo L; Department of Neurology, Clinica San Lucas, Neuquen, Argentina.
  • Reyes G; Department of Neurology, Hospital de Pediatría Juan P. Garrahan, Buenos Aires, Argentina.
  • Chacón S; Pediatric Neurology Center CENI, Gualeguaychú, Argentina.
  • Gallo A; Department of Neurology, Hospital de Pediatría Juan P. Garrahan, Buenos Aires, Argentina.
  • Buompadre C; Department of Neurology, Hospital de Pediatría Juan P. Garrahan, Buenos Aires, Argentina.
Epilepsy Behav ; 126: 108451, 2022 01.
Article em En | MEDLINE | ID: mdl-34864379
OBJECTIVE: We studied cases with long-lasting epileptic spasms (ES) considered as a spasm status analyzing type of epilepsy, epileptic syndrome, etiology, treatment, and outcome in 21 patients. METHODS: We evaluated the charts of 21 patients seen between June 2006 and July 2017 who met the electroclinical diagnostic criteria of a spasm status. The spasm status was defined as continuous ES lasting 30 min or longer. RESULTS: The type of ES was mixed in nine patients, flexion in seven, and extension in five. Epileptic spasms were asymmetric in three patients and unilateral in two. They occurred on awakening in all patients, while during sleep they decreased in all and disappeared in three cases. The duration of the spasm status ranged from 40 min to 15 days according to the seizure diaries of patients and video-EEG recordings. Two well-defined subgroups of patients were recognized; the first included patients with West syndrome (WS) and the second other types of severe non-West epilepsy syndromes. The spasm status responded well to oral vigabatrin (VGB) in four patients, oral topiramate (TPM) in three, oral corticosteroids in one, and cannabidiol in another patient. A good response was observed with benzodiazepines in six patients, with phenytoin (PH) in two, and with phenobarbital (PB) in one. Adrenocorticotropic hormone (ACTH) was effective in one patient and the ketogenic diet in two. Prognosis depends on the etiology. CONCLUSION: In this study we identified patients with WS and other types of severe non-West epilepsy syndromes who had a particular type of long-lasting ES that, in spite of its long duration does not strictly meet the criteria of the International League against Epilepsy (ILAE) classification of status epilepticus, may be considered a spasm status.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espasmos Infantis / Epilepsia Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies Limite: Child / Humans / Infant Idioma: En Revista: Epilepsy Behav Assunto da revista: CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espasmos Infantis / Epilepsia Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies Limite: Child / Humans / Infant Idioma: En Revista: Epilepsy Behav Assunto da revista: CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de publicação: Estados Unidos