Two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum.
Synth Syst Biotechnol
; 6(4): 446-451, 2021 Dec.
Article
em En
| MEDLINE
| ID: mdl-34901483
ABSTRACT
Phytopathogenic fungi have attracted great attention as a promising source for new drug discovery. In the progress of our ongoing study for bioactive natural products from an in-house phytopathogenic fungi library, a pathogenic fungus, Fusarium proliferatum strain 13294 (FP13294), was selected for chemical investigation. Two novel aliphatic unsaturated alcohols named fusariumnols A and B (1 and 2), together with one previously characterized sesquiterpenoid lignoren (3) were identified. Structures of 1-3 were assigned by mass spectrometry and NMR spectroscopy. Their bioactivities were assessed against Staphylococcus epidermidis, S. aureus, and Methicillin-resistant S. aureus (MRSA). Compounds 1 and 2 exhibited weak antibacterial activity against S. epidermidis (MIC = 100 µM).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Synth Syst Biotechnol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China