Components of the phosphatidylserine endoplasmic reticulum to plasma membrane transport mechanism as targets for KRAS inhibition in pancreatic cancer.

Kattan, Walaa E; Liu, Junchen; Montufar-Solis, Dina; Liang, Hong; Brahmendra Barathi, Bhargavi; van der Hoeven, Ransome; Zhou, Yong; Hancock, John F

Kattan, Walaa E; Liu, Junchen; Montufar-Solis, Dina; Liang, Hong; Brahmendra Barathi, Bhargavi; van der Hoeven, Ransome; Zhou, Yong; Hancock, John F.

Afiliação

Kattan WE; Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77030.
Liu J; Cancer Biology Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences at Houston, Houston, TX 77030.
Montufar-Solis D; Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77030.
Liang H; Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77030.
Brahmendra Barathi B; Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77030.
van der Hoeven R; Cancer Biology Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences at Houston, Houston, TX 77030.
Zhou Y; Department of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center, Houston, TX 77054.
Hancock JF; Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77030.

Proc Natl Acad Sci U S A ; 118(51)2021 12 21.

Article em En | MEDLINE | ID: mdl-34903667

Assuntos

Antineoplásicos/farmacologia; Membrana Celular/metabolismo; Retículo Endoplasmático/metabolismo; Fosfatidilserinas/metabolismo; Proteínas Proto-Oncogênicas p21(ras)/antagonistas & inibidores; Receptores de Esteroides/metabolismo; 1-Fosfatidilinositol 4-Quinase/antagonistas & inibidores; 1-Fosfatidilinositol 4-Quinase/genética; 1-Fosfatidilinositol 4-Quinase/metabolismo; Proteínas Adaptadoras de Transdução de Sinal/genética; Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Animais; Transporte Biológico/efeitos dos fármacos; Linhagem Celular Tumoral; Sistemas de Liberação de Medicamentos; Técnicas de Silenciamento de Genes; Humanos; Camundongos; Camundongos Nus; Inibidores de Proteases/farmacologia; Proteínas Proto-Oncogênicas p21(ras)/genética; Proteínas Proto-Oncogênicas p21(ras)/metabolismo; Receptores de Esteroides/genética; Simeprevir/farmacologia; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

KRAS; ORP5; ORP8; PI4KA; phosphatidylserine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatidilserinas / Receptores de Esteroides / Membrana Celular / Proteínas Proto-Oncogênicas p21(ras) / Retículo Endoplasmático / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos

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