Discordance between TST and QFT-TBGold Plus for Latent Tuberculosis Screening among Under-Five Children: An Interim Analysis.
J Trop Pediatr
; 67(6)2021 12 08.
Article
em En
| MEDLINE
| ID: mdl-34904674
The current study focuses on discordance and concordance between tuberculin skin test (TST) and fourth-generation QuantiFERON (QFT)-TB Gold Plus [interferon gamma (INF-γ) release assays (IGRA)] for latent tuberculosis infection (LTBI) diagnosis among at-risk under-five children who are underweight and/or who have history of contact with active tuberculosis patients. The IGRA prevalence came out to be 11.7% (95% CI 8.115.3%) whereas the TST prevalence turned out to be 22.7% (95% CI 18.027.4%). A stronger concordance was observed between IGRA and TST among the age group of 2 to 5 years, and a relatively fair one for children below the age of 1 year. The present study strongly recommends to include both TST and IGRA test for the diagnosis of LTBI with respect to Indian pediatric population. This study also suggests the importance of repetition of IGRA for TST positive patients. Another vital opinion that is showcased in the present study is the inclusion of undernourished pediatric population residing in at-risk areas like urban slums for routine LTBI screening programs.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tuberculose Latente
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
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Risk_factors_studies
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Screening_studies
Limite:
Child
/
Humans
Idioma:
En
Revista:
J Trop Pediatr
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Índia