Is it time to rethink the burden of non-coeliac gluten sensitivity? A systematic review.
Minerva Gastroenterol (Torino)
; 68(4): 442-449, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-34929997
ABSTRACT
INTRODUCTION:
Non-coeliac gluten sensitivity (NCGS) is still a poorly defined clinical condition. This review aims to describe the clinical features of subjects with a symptomatic response to gluten intake, and to estimate the prevalence of NCGS. EVIDENCE ACQUISITION Literature search was conducted in accordance with PRISMA recommendations. The PubMed database was searched for original articles until 1st June 2020. EVIDENCESYNTHESIS:
We identified 30 relevant articles, including 14 studies that investigated NCGS through a double-blind, placebo-controlled crossover trial (DBPCC), and 16 that examined the role of gluten in causing symptoms without a DBPCC. We found that regardless of the diagnostic work up, gluten-sensitive patients were predominately middle-aged females complaining of abdominal pain, bloating and diarrhea. The pooled prevalence of NCGS after DBPCC was 24% (5-34%). Subjects with irritable bowel syndrome or self-reporting gluten intolerance accounted for the vast majority of the patients who did not start a DBPCC. A symptomatic response to a gluten-free diet (GFD) occurred in between 7% and 93% of patients. No data on long-term outcomes of NCGS individuals were reported.CONCLUSIONS:
Clinical features of NCGS patients did not differ among all the included studies, whereas prevalence figures are rather heterogeneous. Long-term benefit of a GFD on these patients still needs to be ascertained.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença Celíaca
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Síndrome do Intestino Irritável
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Doenças do Sistema Imunitário
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Síndromes de Malabsorção
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Guideline
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Risk_factors_studies
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Systematic_reviews
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Minerva Gastroenterol (Torino)
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Itália
País de publicação:
IT
/
ITALIA
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ITALY
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ITÁLIA