A stepwise mutagenesis approach using histidine and acidic amino acid to engineer highly pH-dependent protein switches.

Zou, Wenjun; Huang, Chuncui; Sun, Qing; Zhao, Keli; Gao, Huanyu; Su, Rong; Li, Yan

Zou, Wenjun; Huang, Chuncui; Sun, Qing; Zhao, Keli; Gao, Huanyu; Su, Rong; Li, Yan.

Afiliação

Zou W; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049 China.
Huang C; Key Laboratory of Interdisciplinary Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 China.
Sun Q; Key Laboratory of Interdisciplinary Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 China.
Zhao K; Key Laboratory of Interdisciplinary Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 China.
Gao H; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049 China.
Su R; Key Laboratory of Interdisciplinary Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 China.
Li Y; Key Laboratory of Interdisciplinary Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 China.

3 Biotech ; 12(1): 21, 2022 Jan.

Article em En | MEDLINE | ID: mdl-34956814

Palavras-chave

Antibody engineering; Carcinoembryonic antigen; Hot-spot residues; Tumor microenvironments

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: 3 Biotech Ano de publicação: 2022 Tipo de documento: Article