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Cameroonian Spice Extracts Modulate Molecular Mechanisms Relevant to Cardiometabolic Diseases in SW 872 Human Liposarcoma Cells.
Atchan Nwakiban, Achille Parfait; Passarelli, Anna; Da Dalt, Lorenzo; Olivieri, Chiara; Demirci, Tugba Nur; Piazza, Stefano; Sangiovanni, Enrico; Carpentier-Maguire, Eugénie; Martinelli, Giulia; Shivashankara, Shilpa Talkad; Manjappara, Uma Venkateswaran; Tchamgoue, Armelle Deutou; Agbor, Gabriel Agbor; Kuiate, Jules-Roger; Daglia, Maria; Dell'Agli, Mario; Magni, Paolo.
Afiliação
  • Atchan Nwakiban AP; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 96, Cameroon.
  • Passarelli A; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.
  • Da Dalt L; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.
  • Olivieri C; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.
  • Demirci TN; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.
  • Piazza S; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.
  • Sangiovanni E; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.
  • Carpentier-Maguire E; Department of Science and Technology, University of Lille, Rue de Lille, 59160 Lille, France.
  • Martinelli G; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.
  • Shivashankara ST; Department of Lipid Science, CSIR-Central Food Technological Research Institute (CFTRI), Mysore 570 020, India.
  • Manjappara UV; Department of Lipid Science, CSIR-Central Food Technological Research Institute (CFTRI), Mysore 570 020, India.
  • Tchamgoue AD; Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaoundé 4123, Cameroon.
  • Agbor GA; Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaoundé 4123, Cameroon.
  • Kuiate JR; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 96, Cameroon.
  • Daglia M; Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy.
  • Dell'Agli M; International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China.
  • Magni P; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.
Nutrients ; 13(12)2021 Nov 26.
Article em En | MEDLINE | ID: mdl-34959824
The molecular pathophysiology of cardiometabolic diseases is known to be influenced by dysfunctional ectopic adipose tissue. In addition to lifestyle improvements, these conditions may be managed by novel nutraceutical products. This study evaluatedthe effects of 11 Cameroonian medicinal spice extracts on triglyceride accumulation, glucose uptake, reactive oxygen species (ROS) production and interleukin secretion in SW 872 human adipocytes after differentiation with 100 µM oleic acid. Triglyceride content was significantly reduced by all spice extracts. Glucose uptake was significantly increased by Tetrapleura tetraptera, Aframomum melegueta and Zanthoxylum leprieurii. Moreover, Xylopia parviflora, Echinops giganteus and Dichrostachys glomerata significantly reduced the production of ROS. Concerning pro-inflammatory cytokine secretion, we observed that Tetrapleura tetraptera, Echinops giganteus, Dichrostachys glomerata and Aframomum melegueta reduced IL-6 secretion. In addition, Xylopia parviflora, Monodora myristica, Zanthoxylum leprieurii, and Xylopia aethiopica reduced IL-8 secretion, while Dichrostachys glomerata and Aframomum citratum increased it. These findings highlight some interesting properties of these Cameroonian spice extracts in the modulation of cellular parameters relevant to cardiometabolic diseases, which may be further exploited, aiming to develop novel treatment options for these conditions based on nutraceutical products.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Especiarias / Adipócitos / Suplementos Nutricionais / Síndrome Metabólica Limite: Humans Idioma: En Revista: Nutrients Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Camarões País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Especiarias / Adipócitos / Suplementos Nutricionais / Síndrome Metabólica Limite: Humans Idioma: En Revista: Nutrients Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Camarões País de publicação: Suíça